Results 41 to 50 of about 88,194 (298)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Exploring the extent of social expenditures in the Ottoman State: poor relief payment

Revista de Historia Industrial
This study investigates the determinants influencing the amount of poor relief payments within the Ottoman Empire, utilizing salary data from the 1904 register of the needy.
Sahin Yesilyurt, Abudllah Tirgil
doaj   +1 more source

Anticipation and choice heuristics in the dynamic consumption of pain relief [PDF]

, 2014
Humans frequently need to allocate resources across multiple time-steps. Economic theory proposes that subjects do so according to a stable set of intertemporal preferences, but the computational demands of such decisions encourage the use of formally ...
Dayan, P., Story, G., Dayan, P, Dolan, R., Vlaev, I, Ben Seymour, Raymond J. Dolan (209991), Dolan, Raymond, Seymour, B., Story, Giles W., Darzi, Ara, Vlaev, I., Darzi, A, Vlaev, Ivo, Seymour, B, Ara Darzi, Giles W. Story (488406), Ara Darzi (31515), Dolan, RJ, Peter Dayan (26734), Giles W Story, Ivo Vlaev (707044), Dolan, R. ; https://orcid.org/, Story, GW, Raymond J Dolan, ,, Peter Dayan, Dayan, Peter, Ben Seymour (302807), Darzi, A., Ivo Vlaev, Seymour, Ben   +31 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Investigation of Valve Seat Cone Angle on Small Opening Direct-Acting Relief Valve Cavitation Noise

Machines
Direct-acting relief valves are important pressure-control components in hydraulic systems; however, noise problems are now common. This study aimed to reduce and numerically analyze the valve cavitation and noise using the Zwart–Gerber–Belamri (ZBG ...
Tiechao Qiu, Liu Yang, Jiannan Zhang, Zhanqi Wang, Yanhe Song, Chao Ai   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Multinarasi Relief Yeh Pulu Basis Penciptaan Seni Lukis Kontemporer

Mudra: Jurnal Seni Budaya, 2018
Kajian ini merupakan skema penelitian terapan, yang bertujuan untuk mengungkap konsep multinarasi relief Yeh Pulu, Bedulu, Gianyar, Bali, sebagai basis penciptaan seni lukis kontemporer.
I Wayan Adnyana, A.A Rai Remawa, Ni Luh Desi In Diana Sari   +2 more
doaj   +1 more source

Impact of end-of-life respiratory modalities on quality of dying and death and symptom relief in patients with interstitial lung disease: a multicenter descriptive cross-sectional study

Respiratory Research, 2022
Background Respiratory modalities applied at the end of life may affect the burden of distressing symptoms and quality of dying and death (QODD) among patients with end-stage interstitial lung disease (ILD); however, there have been few studies into ...
Takafumi Koyauchi, Yuzo Suzuki, Kazuki Sato, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Koshi Yokomura, Shiro Imokawa, Hidenori Nakamura, Tatsuya Morita, Takafumi Suda   +14 more
doaj   +1 more source

Pain Relief in Childbirth: Changing Historical and Feminist Perspectives [PDF]

Anaesthesia and Intensive Care, 2015
Pain during human childbirth is ubiquitous and severe. Opium and its derivatives constitute the oldest effective method of pain relief and have been used in childbirth for several thousand years, along with numerous folk medicines and remedies. Interference with childbirth pain has always been criticised by doctors and clergy.
openaire   +2 more sources