Results 51 to 60 of about 347,588 (311)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Lo Jee-Ou's memorandum to Chambers Chow and H-T Yang on June 15, 1946, Hankow (Hankou) [China] [PDF]
, 1946 A memorandum from Lo Jee-Ou to Chambers Chow and H-T Yang on June 15, 1946, regarding urgent problems with relief work.
Lo, Jee-Ou
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Exploration of critical moisture content of coal based on CH4, N2, and CO2 adsorption experiments
Journal of Applied Science and EngineeringTwo types of experiments were designed to systematically analyze the mechanisms regulating gas adsorption by the wet phase state of the coal body and the critical moisture.
Xiaotong Lu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Administration of relief in counties using federal relief funds [PDF]
, 1933 KERC bulletin ; no. 3A (June 15, 1933)"There is submitted herewith instructions and regulations together with copies of laws pertaining to the administration of relief in those counties using Federal Relief Funds furnished by the United States ...
Kansas Emergency Relief Committee.
core
Nordisk Judaistik, 2020 Swedish Jews’ supposed inactivity over Europe’s persecuted Jews during the Holocaust has been a prevalent discourse during the post-war period. This article ponders the origins of that discourse and how it affects how and what Swedish Jews narrate about ...
Malin Thor Tureby
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source