Results 71 to 80 of about 347,588 (311)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
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Make Debt Relief Work: Proposals for the G7 [PDF]
, 2000 In spite of the fanfare, progress on debt relief has been agonizingly slow. Debt servicing continues to suck resources away from the fight against poverty and contributes to child deaths more than 20 times the rate in rich countries. Countries should get
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Results in EngineeringThe key to applying freezing coring technology in measuring coal seam gas content lies in accurately estimating the refrigerant dosage. As coring depth increases, the heat generated by the coring tube rises, and accordingly, the required refrigerant ...
Shijie Li +5 more
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Städtische Armenbehörde und Wohltätigkeitsvereine in Göttingen 1870 bis 1914
Österreichische Zeitschrift für Geschichtswissenschaften, 2015 This paper focuses on poor relief in Göttingen in the late 19th century. It provides insight into the practical cooperation of different actors in a “mixed economy of welfare”. Different actors played an important role in providing help to the poor: the
Jürgen Schallmann
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Kansas Emergency Relief Committee bulletins, 1932-1933 [PDF]
, 1932 Scanned from a bound volume.KERC bulletin ; 1932-1933.Bulletin No. 1 (Aug 6, 1932) -- The Lever of State Relief (Aug 6, 1932) -- Bulletin No. 1A For County Federal Relief Committeemen (Aug 6, 1932) -- Bulletin No.
Kansas Emergency Relief Committee.
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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Relief supplies requested by Siangyang (Xiangyang) St. Teresa's Catholic Orphanage [China] and R. Galaida's recommendations on May 25, 1946 [PDF]
, 1946 A list of relief supplies requested by Siangyang (Xiangyang) St. Teresa's Catholic Orphanage, and also R.
Galaida, Rose, 1894-1983
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A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers +7 more
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