Results 41 to 50 of about 254,272 (263)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Relieving DELLA Restraint

Science, 2003
Phytohormones such as gibberellins are known to promote plant growth, but it is unclear how they do this. In a Perspective, Harberd discusses new work ( Sasaki et al.) that reveals the biochemical basis of the relief-of-restraint model of plant growth regulation.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Estudio comparativo de la densidad del complejo de orugas cortadoras (Lepidoptera: Noctuidae) en diferentes ambientes y cultivos antecesores en la región subhúmeda pampeana central

Semiárida, 2018
El objetivo del estudio fue determinar si la densidad de orugas cortadoras es afectada por el cultivo antecesor y el ambiente. Tres lotes de cada antecesor fueron seleccionados en 2014, y otros tres en 2015.
Andres Corró Molas, Estela Baudino, Juliana Vilches, Walter Guillot Giraudo, Francisco Babinec, Graciela Vergara, Selene Niveyro, Eugenia Ghironi, Carlos Ferrero   +8 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impact of the "salary scholarship" impact profile and student achievement.

RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2013
In Spain, within the framework of the Strategy 2015, the implementation of scholarships, grants and wages especially adapted to the new situation of the European Higher Education, intended to ensure access to university education to those most ...
Berlanga, Vanesa, Figuera, Pilar, Pons-Fanals, Ernest   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Evaluación de los índices de calidad del suelo de diversos cultivos en diferentes condiciones topográficas, parroquia El Progreso, El Oro

Agroecosistemas, 2020
La calidad del suelo es una herramienta de valoración que facilita la aplicación de prácticas de manejo que promuevan sistemas agronómicos sostenibles. El objetivo de caracterizar varios usos de suelo en función de varias propiedades físicos-químicas del
Barrera León, Jenner , Barrezueta Unda, Salomón , García Batista, Rigoberto   +2 more
doaj  

Scientific journals on Education in Spain: evolution and prospects for the future.

RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2014
The Spanish scientific journals on education have experience an exponential growth in recent decades. The reasons are closely related to the supranational policies of university quality assessment, with specific emphasis on research output with "impact".
Ruiz-Corbella, Marta, Galán, Arturo, Diestro, Alfonso   +2 more
doaj   +1 more source