Results 71 to 80 of about 1,091,662 (280)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Estudio comparativo de la densidad del complejo de orugas cortadoras (Lepidoptera: Noctuidae) en diferentes ambientes y cultivos antecesores en la región subhúmeda pampeana central

Semiárida, 2018
El objetivo del estudio fue determinar si la densidad de orugas cortadoras es afectada por el cultivo antecesor y el ambiente. Tres lotes de cada antecesor fueron seleccionados en 2014, y otros tres en 2015.
Andres Corró Molas, Estela Baudino, Juliana Vilches, Walter Guillot Giraudo, Francisco Babinec, Graciela Vergara, Selene Niveyro, Eugenia Ghironi, Carlos Ferrero   +8 more
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mapa geomorfológico preliminar del municipio de Mayarí a escala 1: 100 000

Ciencia & Futuro, 2016
Se determinaron los tipos de relieve que conforman el municipio de Mayarí. Para esto se digitalizaron las hojas topográficas que conforman el área de estudio, obteniendo el modelo digital de la misma.
Sergio Greenidge-Moro
doaj  

Evaluación de los índices de calidad del suelo de diversos cultivos en diferentes condiciones topográficas, parroquia El Progreso, El Oro

Agroecosistemas, 2020
La calidad del suelo es una herramienta de valoración que facilita la aplicación de prácticas de manejo que promuevan sistemas agronómicos sostenibles. El objetivo de caracterizar varios usos de suelo en función de varias propiedades físicos-químicas del
Barrera León, Jenner , Barrezueta Unda, Salomón , García Batista, Rigoberto   +2 more
doaj  

On mountain waves

Geofísica Internacional, 1972
El presente trabajo examina el problema de las condiciones a la frontera en el estudio de la propagación de las ondas de relieve. Se demuestra qué dentro del marco de la teoría clásica, no se necesita una condición límite en la frontera superior.
Leon Covez
doaj   +1 more source

Relieve the discomfort of dysmenorrhea & herbal remedies

, 2008
[No abstract ...
Jouybari, L., Sanagoo, A., Shojaa, M.
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source