Results 81 to 90 of about 385,829 (304)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Longitudinal analysis of Spanish doctoral theses in education (1841-2012).

RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2014
This article analyzes the research output of doctoral theses in the field of Education defended in Spain from 1841-2012. It offers a quantified global and diachronic view of such series.
Fernández-Bautista, Andrés, Torralbo, Manuel, Fernández-Cano, Antonio   +2 more
doaj   +1 more source

RELIEVE cumple 10 años, pero … ¿cómo fue el primero?. [RELIEVE turns 10 years, but... how it was the first?]

, 2005
The author remembers the beginnings of RELIEVE, the first electronic journal that was authorized in Spain. The evolution of electronic publishings in these ten years is also analyzed..
Gregorio Rodriguez
core  

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Relieve

, 2014
Capilla del Sagrado Corazón. Presbiterio. Relieve.-Anónimo Granadino.- El retablo presenta como elementos decorativos placas recortadas, estípites, rocallas, motivos vegetales y ...
Gómez Alvarez de Salina, Inmaculada
core   +9 more sources

Adapting to the European Higher Education Area a questionnaire on student opinion about the teaching of lecturers.

RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2014
The aim of this work is to present the adaptation to the European Higher Education Area of a questionnaire on the opinions of University of the Basque Country students about their lecturers teaching process. This process undertaken at the University used
Lukas, José Francisco, Santiago, Karlos, Etxeberria, Juan, Lizasoain, Luis   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Competencias docentes en secundaria. Análisis de perfiles de profesorado.

RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2014
En el presente trabajo se muestran los resultados de una investigación cuyo objetivo ha sido analizar la importancia que el profesorado de secundaria de la provincia de Castellón otorga a las competencias docentes y determinar los perfiles profesionales ...
Ferrández-Berrueco, Reina, Sánchez-Tarazaga, Lucía   +1 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

El Transporte Terrestre a través de la Cordillera Cantábrica en Tiempos de Felipe II. Un Estudio a partir de la Correspondencia de Simón Ruiz con Laredo

Studia Historica: Historia Moderna, 2012
El presente trabajo analiza las condiciones y costes del transporte terrestre en tiempos de Felipe II en el ámbito de las relaciones comerciales entre Castilla y el espacio atlántico septentrional, a partir de la información proporcionada por las cartas ...
Oscar LUCAS VILLANUEVA
doaj