Results 71 to 80 of about 126,238 (250)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Investigaciones Geográficas, 2016 Las características morfológicas del relieve y la cuantificación morfométrica de sus magnitudes son elementos esenciales para la interpretación de la influencia de este en la dinámica hidrogeomorfológica de cuencas de drenaje en ambientes montañosos. Por
Williams José Méndez Mata
doaj
RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2013 En este artículo se presentan los resultados más relevantes de una investigación en la que se analizan las opiniones del profesorado del área de Fresno (California Central, EEUU) respecto a los efectos que tiene el uso de los dispositivos móviles en los
Navaridas, Fermín +2 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Investigaciones Geográficas, 2009 Son pocos los estudios enfocados en la evaluación de los errores inherentes a los modelos digitales de elevación (MDE). Por esta razón se evaluaron los errores de los MDE obtenidos por diferentes metodos de interpolación (ARC/INFO, IDRISI, ILWIS y NEW ...
Azucena Pérez Vega, Jean François Mas
doaj
Twenty years of electronic publishing and open access: a pioneer reaches maturity
RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2014 RELIEVE reaches 20 years, a milestone in electronic publishing and the open access to educational research. We review some of the achievements and future prospects, as well as analyze some circumstances of journal evaluation processes.
Aliaga, Francisco M.
doaj +1 more source
Mapa de las unidades de relieve de España
, 2010 Ensino Fundamental Final::GeografiaLa imagen muestra las unidades del relieve de España y de las islas Baleares, siendo: el planalto, las cordilleras interiores, exteriores y que cercan el planalto, las depresiones perifericas, las planicies del litoral ...
Bermúdez, José Alberto
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Longitudinal analysis of Spanish doctoral theses in education (1841-2012).
RELIEVE: Revista Electrónica de Investigación y Evaluación Educativa, 2014 This article analyzes the research output of doctoral theses in the field of Education defended in Spain from 1841-2012. It offers a quantified global and diachronic view of such series.
Fernández-Bautista, Andrés +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source