Results 41 to 50 of about 49,936 (298)

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

Frontiers in Neuroscience, 2014
In accordance with the prominent role of orexins in the maintenance of wakefulness via activation of orexin-1 (OX1R) and orexin-2 (OX2R) receptors, various dual OX1/2R antagonists have been shown to promote sleep in animals and humans.
Christine eDugovic, Jonathan E Shelton, Sujin eYun, Pascal eBonaventure, Brock T Shireman, Timothy W Lovenberg   +5 more
doaj   +1 more source

A study on sleep apnea in patients with abnormal sewda type of depression

Traditional Medicine and Modern Medicine, 2020
Objective: To preliminarily investigate the clinical features and PSG in abnormal sewda-type depressive insomnia. Methods: A total of 127 abnormal sewda-type depressive insomnia patients were evaluated with overnight PSG, and 32 normal participants were ...
Aman Gul, Nassirhadjy Memtily, Pirdun Mijit, Palidan Wushuer, Ainiwaer Talifu, Mihriban Imin, Hua Rui, Zuhoumaer Nuermaimaiti   +7 more
doaj   +1 more source

Neurobehavioral Associations with NREM and REM Sleep Architecture in Children with Autism Spectrum Disorder

Children, 2022
Objective: Insomnia and daytime behavioral problems are common issues in pediatric autism spectrum disorder (ASD), yet specific underlying relationships with NonRapid Eye Movement sleep (NREM) and Rapid Eye Movement (REM) sleep architecture are ...
Jennifer Nguyen, Bo Zhang, Ellen Hanson, Dimitrios Mylonas, Kiran Maski   +4 more
doaj   +1 more source

The Natural History of Insomnia: Acute Insomnia and First-onset Depression

, 2013
Study Objectives: While many studies have examined the association between insomnia and depression, no studies have evaluated these associations 1) within a narrow time frame, 2) with specific reference to acute & chronic insomnia, and 3) using ...
Michael L. Perlis, Ellis, Jason, Ellis, JG, Bastien, Célyne, Espie, Colin, Bastien, Célyne H., Ellis, Jason G., Gardani, M, Bastien, CH, Célyne H. Bastien, Espie, CA, Perlis, Michael L., Colin A. Espie, Perlis, Michael, Gardani, Maria, Jason G. Ellis, Perlis, ML, Espie, Colin A., Maria Gardani   +18 more
core   +1 more source

A Hypothalamic Switch for REM and Non-REM Sleep [PDF]

Neuron, 2018
Rapid eye movement (REM) and non-REM (NREM) sleep are controlled by specific neuronal circuits. Here we show that galanin-expressing GABAergic neurons in the dorsomedial hypothalamus (DMH) comprise separate subpopulations with opposing effects on REM versus NREM sleep.
Chen, Kai-Siang, Xu, Min, Zhang, Zhe, Chang, Wei-Cheng, Gaj, Thomas, Schaffer, David V, Dan, Yang   +6 more
openaire   +4 more sources

Essential roles of GABA transporter-1 in controlling rapid eye movement sleep and in increased slow wave activity after sleep deprivation. [PDF]

PLoS ONE, 2013
GABA is the major inhibitory neurotransmitter in the mammalian central nervous system that has been strongly implicated in the regulation of sleep. GABA transporter subtype 1 (GAT1) constructs high affinity reuptake sites for GABA and regulates GABAergic
Xin-Hong Xu, Wei-Min Qu, Min-Juan Bian, Fang Huang, Jian Fei, Yoshihiro Urade, Zhi-Li Huang   +6 more
doaj   +1 more source

Antidepressants and their effect on sleep

, 2005
Given the relationship between sleep and depression, there is inevitably going to be an effect of antidepressants on sleep. Current evidence suggests that this effect depends on the class of antidepressant used and the dosage.
Mayers, Andrew G., Baldwin, David S., Mayers, A.G., Baldwin, D.S.   +3 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

A rare case of REM sleep-related bradyarrhythmia syndrome with concomitant severe hypertension: a case report and a review of literature

Acta Medica Lituanica, 2018
Introduction. Rapid eye movement (REM) sleep-related bradyarrhythmia syndrome is characterized by pathological asystoles during the REM sleep phase. It is a rare rhythm disorder, being reported only few times in the literature.
Gabrielius Jakutis, Vytautas Juknevičius, Juratė Barysienė, Dalia Matačiūnienė, Birutė Petrauskienė, Žaneta Petrulionienė, Aleksandras Laucevičius   +6 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source