Results 81 to 90 of about 472,554 (253)

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Selective REM Sleep Deprivation Improves Expectation-Related Placebo Analgesia.

PLoS ONE, 2015
The placebo effect is a neurobiological and psychophysiological process known to influence perceived pain relief. Optimization of placebo analgesia may contribute to the clinical efficacy and effectiveness of medication for acute and chronic pain ...
Florian Chouchou, Jean-Marc Chauny, Pierre Rainville, Gilles J Lavigne   +3 more
doaj   +1 more source

The hidden burden of sleep in adolescents with idiopathic generalized epilepsy

Epileptic Disorders, EarlyView.
Abstract Background Idiopathic Generalized Epilepsies (IGEs) are electroclinical syndromes characterized by distinct seizure types, EEG patterns, and presumed polygenic inheritance. While seizure prognosis is often favorable, sleep disturbances, behavioral and emotional difficulties, and executive function impairment are common, especially during ...
Carlo Alberto Quaranta, Martina Paola Zanaboni, Elena Ripamonti, Gaia Garghetti, Massimiliano Celario, Serena Grumi, Helene Vitali, Valentina De Giorgis, Ludovica Pasca   +8 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

The relationship between psychosocial job stressors and insomnia: The mediating role of psychological capital

Nursing Open, EarlyView., 2023
Abstract Aim This study aimed to examine the association of job‐related stressors and insomnia; to determine the association of psychological capital and insomnia; and to explore whether psychological capital mediates the association between job‐related stressors and insomnia among Chinese nurses. Design A cross‐sectional questionnaire survey.
Juan Du, Shi‐Zhe He, Min‐Jie Li, Chao Wu, Wen‐Kai Zheng, Lin‐Yuan Zhang, Chun‐Ni Heng, Chun‐Ping Ni, Hong‐Juan Lang   +8 more
wiley   +1 more source

Revisiting the concept that interictal implies asymptomatic: Pulse wave amplitude drops uncover autonomic responses during generalized paroxysmal fast activities

Epilepsia, EarlyView.
Abstract Objective Interictal electroencephalographic (EEG) activities are generally considered asymptomatic. Pulse wave amplitude drop (PWAD) is a marker of autonomic nervous system (ANS) reactivity linked to cardiovascular risk. Generalized paroxysmal fast activity (GPFA) is a major EEG pattern in different epileptic conditions.
Julie Lévi‐Strauss, Valerio Frazzini, Claude Adam, Isabelle Gourfinkel‐An, Sophie Dupont, Vincent Navarro, Vi‐Huong Nguyen‐Michel   +6 more
wiley   +1 more source

Neuronal avalanches differ from wakefulness to deep sleep - evidence from intracranial depth recordings in humans [PDF]

, 2013
Neuronal activity differs between wakefulness and sleep states. In contrast, an attractor state, called self-organized critical (SOC), was proposed to govern brain dynamics because it allows for optimal information coding.
Viola Priesemann, Mario Valderrama, Valderrama, Mario, Michael Wibral, Viola Priesemann (383305), Michel Le Van Quyen, Michel Le Van Quyen (173314), Mario Valderrama (173279), Le Van Quyen, Michel, Priesemann, Viola, Michael Wibral (383303), Wibral, Michael   +11 more
core   +1 more source

Are sleep paralysis and false awakenings different from REM sleep and from lucid REM sleep? A spectral EEG analysis

, 2021
International audienceStudy Objectives:To determine the polysomnography characteristics during sleep paralysis, false awakenings, and lucid dreaming (which are states intermediate to rapid eye movement [REM] sleep and wake but exceptionally observed in ...
Leu- Semenescu, Smaranda, Mainieri, Greta, Champetier, Pierre, Dodet, Pauline, Gales, Ana, Arnulf, Isabelle, Maranci, Jean-Baptiste   +6 more
core   +1 more source

Epileptic arousals: A neglected clinical entity

Epilepsia, EarlyView.
Abstract Objective Epileptic arousals (EAs) are seizures characterized solely by arousal from sleep. EAs are unrecognized in current seizure classifications. Their subtle semiology and inconsistently detectable ictal activity in scalp electroencephalography (EEG) complicate differentiation from physiological arousals (PAs). This study characterizes EAs
Lea Fisel, Nóra Pető, Sotirios Kalousios, Nicolas Zabler, Armin Brandt, Peter C. Reinacher, Dieter Riemann, Mohammad F. Khazali, Andreas Schulze‐Bonhage   +8 more
wiley   +1 more source

Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Theta oscillations (4–12 Hz) are a prominent network rhythm within hippocampal and parahippocampal structures. Driven by cholinergic and γ‐aminobutyric acidergic inputs originating from the medial septum, physiological theta gates network excitability to control spatial navigation, memory encoding, and sensorimotor integration during specific ...
Maxime Lévesque, Massimo Avoli
wiley   +1 more source