Results 71 to 80 of about 472,554 (253)

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Neural circuitry of rapid eye movement sleep homeostasis: Mechanistic insights and pathological implications

Sleep Research
Rapid eye movement (REM) sleep is a unique brain state crucial for emotion, memory, and plasticity. Unlike well‐understood non‐REM (NREM) sleep homeostasis, REM sleep homeostasis remains less clearly defined.
Ting He
doaj   +1 more source

Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy

Neurobiology of Disease, 2018
The lateral hypothalamus contains neurons producing orexins that promote wakefulness and suppress REM sleep as well as neurons producing melanin-concentrating hormone (MCH) that likely promote REM sleep.
Fumito Naganuma, Sathyajit S. Bandaru, Gianna Absi, Carrie E. Mahoney, Thomas E. Scammell, Ramalingam Vetrivelan   +5 more
doaj   +1 more source

Gastrodin Improves Cognitive Dysfunction in REM Sleep-Deprived Rats by Regulating TLR4/NF-κB and Wnt/β-Catenin Signaling Pathways

Brain Sciences, 2023
Gastrodin is the active ingredient in Gastrodia elata. Our previous studies demonstrated that gastrodin ameliorated cerebral ischemia–reperfusion and hypoperfusion injury and improved cognitive deficit in Alzheimer’s disease.
Bo Liu, Fei Li, Yunyan Xu, Qin Wu, Jingshan Shi   +4 more
doaj   +1 more source

The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: A double-blind placebo-controlled study

, 2006
Study Objective: Examine the effects of donepezil on sleep and rapid eye movement (REM) sleep electroencephalogram (EEG) in patients with Alzheimer disease, using polysomnography, and the correlation between REM sleep EEG parameters and cognitive scores ...
Ferreira Bertolucci, Paulo Henrique [UNIFESP], Christian Guilleminault, Sergio Tufik, Guilleminault, Christian, Moraes, Walter André dos Santos [UNIFESP], Tufik, Sergio [UNIFESP], Walter André dos Santos Moraes, Ramos, Luiz Roberto [UNIFESP], Poyares, Dalva [UNIFESP], Paulo Henrique Ferreira Bertolucci, Dalva Rollemberg Poyares, Luiz Roberto Ramos   +11 more
core   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

A Language‐Guided Multimodal Foundation Model for Zero‐Shot and Multi‐Task Brain Signal Analysis

Advanced Intelligent Systems, EarlyView.
METIS aligns brain signals with natural‐language instructions to enable zero‐shot and multi‐task brain signal analysis. Pretrained on over 70 000 h of EEG and iEEG recordings, it generalizes across sleep stage classification, epilepsy detection, and neurological disorder diagnosis, providing a scalable foundation model for clinically meaningful brain ...
Mingzhi Chen, Yiyu Gui, Guibo Luo, Yuchao Yang   +3 more
wiley   +1 more source

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Annals of Neurology, EarlyView.
Objectives Apolipoprotein E ε4 (APOE ε4), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathway through which ε4 contributes to Alzheimer's disease vulnerability. However,
Gawon Cho, Anne Chen, Eunyoung Choi, Orfeu M. Buxton, Daniel Kay, Adam Mecca, Brienne Miner   +6 more
wiley   +1 more source

A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder

Scientific Reports, 2021
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by disrupting motor enactments during REM sleep, but also cognitive impairments across several domains.
Amandine Valomon, Brady A. Riedner, Stephanie G. Jones, Keith P. Nakamura, Giulio Tononi, David T. Plante, Ruth M. Benca, Melanie Boly   +7 more
doaj   +1 more source

Wilson?s disease presenting as rapid eye movement sleep behavior disorder: a possible window to early treatment

Arquivos de Neuro-Psiquiatria, 2014
Objective To describe characteristics of REM sleep behavior disorder in Wilson’s disease. Method Questionnaire-based interviews (patients and relatives), neurological examinations, two-week prospective dream-diary, video-polysomnography, transcranial ...
Gotthard G. Tribl, Edson Bor-Seng-Shu, Mateus C. Trindade, Leandro T. Lucato, Manoel J. Teixeira, Egberto R. Barbosa   +5 more
doaj   +1 more source