Results 121 to 130 of about 530,506 (256)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Remaining Useful Life Prediction of Gas Turbine Engine using Autoregressive Model

MATEC Web of Conferences, 2017
Gas turbine (GT) engines are known for their high availability and reliability and are extensively used for power generation, marine and aero-applications.
Ahsan Shazaib, Alemu Lemma Tamiru
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Predicting the Remaining Useful Lifetime of a Proton Exchange Membrane Fuel Cell using an Echo State Network

, 2014
International audienceOne remaining technological bottleneck to develop industrial Fuel Cell (FC) applications resides in the system limited useful lifetime.
Gouriveau, Rafael, Hissel, Daniel, Jemei, Samir, Morando, Simon, Zerhouni, Noureddine   +4 more
core   +1 more source

Bayesian Networks for Remaining Useful Life Prediction

PHM Society European Conference
Remaining useful life (RUL) prediction is a critical task in the field of condition-based maintenance. It is important to perform RUL prediction in a statistical sound way. However, it is not straightforward to properly combine multiple information sources about an asset, such as available statistics, measurements, derived features, and prior knowledge
Erik Hostens, Kerem Eryilmaz, Merijn Vangilbergen, Ted Ooijevaar   +3 more
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Remaining useful life prediction of lithium-ion batteries based on FEEMD-LSTM-TAM-OKELM

AIP Advances
The Remaining Useful Life (RUL) of lithium-ion batteries is an essential indicator in battery management systems. Accurately predicting the RUL of lithium-ion batteries is beneficial for designing a reliable battery system, ensuring the safety and ...
Jingmei Yu, Yaoyang Cai, Yingxin Huang, Xinle Yang   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Improving the prediction accuracy of recurrent neural network by a PID controller.

, 2010
International audienceIn maintenance field, prognostic is recognized as a key feature as the prediction of the remaining useful life of a system which allows avoiding inopportune maintenance spending.
Ciprian Patic, Paul, Gouriveau, Rafael, Zemouri, Ryad   +2 more
core   +1 more source

Prognostic Reasoner based adaptive power management system for a more electric aircraft [PDF]

, 2016
This research work presents a novel approach that addresses the concept of an adaptive power management system design and development framed in the Prognostics and Health Monitoring(PHM) perspective of an Electrical power Generation and distribution ...
Alghassi, Alireza, Jennions, Ian K., Perinpanayagam, Suresh, Sebastian, Robin Kuttikkadan   +3 more
core