Results 121 to 130 of about 10,623,511 (284)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Attentive Bidirectional Long Short-Term Memory Model to Predict the Remaining Useful Life of Aircraft Engines

Accurate Remaining Useful Life (RUL) prediction for turbofan engines remains a challenging issue for the aviation industry due to operational condition variability, sensor noise, and the relatively complex degradation patterns of turbofans.
Deo, Ravinesh C., Seixas Leal, Andreia, Ali, Mumtaz, Prasad, Salvin Sanjesh, Berton, Lilian, De Castro Santos, Luis Carlos   +5 more
core   +1 more source

A Multi-Model Fusion Framework for Aeroengine Remaining Useful Life Prediction

Eng
As the core component of aircraft systems, aeroengines require accurate Remaining Useful Life (RUL) prediction to ensure flight safety, which serves as a key part of Prognostics and Health Management (PHM).
Bing Tan, Yang Zhang, Xia Wei, Lei Wang, Yanming Chang, Li Zhang, Yingzhe Fan, Caio Graco Rodrigues Leandro Roza   +7 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Remaining useful life prediction of lithium-ion batteries: A decomposition-based multi-model prediction approach

AIP Advances
Accurate prediction of the Remaining Useful Life (RUL) of lithium-ion batteries is critical to ensuring the reliability and safety of battery-powered systems.
Shuyi Xue, Lei Li
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Prediction of corroding pipeline remaining life-time using semi-probabilistic approach [PDF]

, 2009
A semi-probabilistic methodology for predicting the remaining strength of submarine pipelines subjected to internal corrosion based on Recommended Practice RP-F101 by Det Norske Veritas (DNV) is described in this paper. It is used to estimate the maximum
Noor, Norhazilan Md., Nor Ozman, Nor Apaziah, Mat Din, Mazura, Yahaya, Nordin, Md. Noor, Norhazilan   +4 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source