474. Real-World Experience of the Comparative Effectiveness and Safety of Remdesivir and Combination Therapy (Remdesivir and Monoclonal Antibodies) in Immunosuppressed Patients with Mild to Moderate COVID-19: A Retrospective Single-center Study in a Community Setting [PDF]
, 2023 Jun Hirai +5 more
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Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT In 2020, COVID‐19 caused a global health crisis, prompting research efforts and accelerating drug development. As part of this response, we conducted a phase 2b, multicentre, open‐label, randomized (1:1) clinical trial to compare the effects of siltuximab versus corticosteroids on disease progression in hospitalized adults with COVID‐19 ...
Lorna Leal +77 more
wiley +1 more source
1149. Resistance Analyses of Patient Viral Samples from the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1) [PDF]
, 2022 Charlotte Hedskog +15 more
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Geriatrics &Gerontology International, Volume 26, Issue 2, February 2026.ABSTRACT Aim The coronavirus disease 2019 (COVID‐19) pandemic has profoundly affected older populations globally. However, limited data are available on the long‐term survival and evolving care needs of older patients with COVID‐19 in Japan. We evaluated 1‐year survival rates and long‐term care needs in this vulnerable population.
Kiyoshi Takemoto +5 more
wiley +1 more source
Remdesivir for the treatment of COVID-19: a systematic review and meta-analysis [PDF]
, 2022 Todd C. Lee +7 more
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Bee products as alternatives in the treatment of viral infections
Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba +3 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai +4 more
wiley +1 more source
Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on N,N′‐Diphenylurea
ChemMedChem, Volume 21, Issue 1, January 2026.Inhibitors of SARS‐CoV‐2 RdRp activity based on N,N′‐diphenylurea scaffold have been identified. Several compounds exhibit residual activity (RA) below 50% in an enzymatic assay (at 10 µM concentration) and improved aqueous solubility compared to the previously reported series of inhibitors.
Artem Chayka +11 more
wiley +1 more source
Oral Melatonin in Critically Ill Patients With COVID‐19: A Quasi‐Experimental Pragmatic Trial
Journal of Medical Virology, Volume 98, Issue 1, January 2026.ABSTRACT Melatonin has demonstrated antioxidant, anti‐inflammatory, and potential antiviral properties. Its therapeutic role in critically ill COVID‐19 patients admitted to intensive care was underexplored at the start of the pandemic. We conducted a quasi‐experimental, pragmatic study over 4 consecutive uninterrupted time periods alternating control ...
Miguel Sánchez‐García +22 more
wiley +1 more source
EXPERIENCE WITH REMDESIVIR FOR THE TREATMENT OF CRITICAL COVID-19 IN A COMMUNITY-BASED HOSPITAL IN EVANSTON, ILLINOIS [PDF]
, 2021 Goar Egoryan +9 more
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