Results 41 to 50 of about 8,220 (235)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Wrocławski Rocznik Historii Mówionej, 2013 Review article: Den Unterdrückten eine Stimme geben. Die International Oral History Association zwischen politischer Bewegung und wissenschaftlichem Netzwerk, Hgg.
Joanna Hytrek-Hryciuk
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Wacław Leszczyński "If you’re from the TPD school, you have a completely different outlook ..."
Wrocławski Rocznik Historii Mówionej, 2017 Prof. Wacław Leszczyński’s account, registered by Marcelina Jakimowicz, was created as part of the documentation and research project of the "Remembrance and Future" Center entitled, "Wrocław science in professor relations".
Katarzyna Bock-Matuszyk
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Wrocławski Rocznik Historii Mówionej, 2015 Every questioning of a witness by a prosecutor is of a legal and formal nature. Its aim is to determine “what really happened”. A historian, if interested not only in reconstruction of the course of events, strives to get to know the world of the witness
Marcin Chorązki
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Timur, Tokhtamysh, and Edigu in Crimea: Historiographical Tradition and Historical Reality » [PDF]
Золотоордынское обозрение, 2015 In the history of the Crimean peninsula, the least studied is a period of the late Middle Ages. To the greatest extent it concerns issues related to the state of the Crimean nomadic and, in particular, of the Crimean ulus of the Golden Horde ...
S.V. Gromenko
doaj
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Feliks Trusiewicz, Tadeusz Szewczyk, and Maria Maleńczak: Testimonies from the Volhynia Massacre
Wrocławski Rocznik Historii Mówionej, 2019 This text provides the source edition of three accounts recorded in 2013 concerning the crimes of Ukrainian nationalists committed during World War II against Poles in Volhynia and Eastern Galicia, referred to as the Volhynia Massacre. Feliks Trusiewicz,
Katarzyna Bock-Matuszyk
doaj +1 more source