Results 101 to 110 of about 15,752 (298)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

Cognitive therapies and their impact on neuropsychiatric symptoms in mild cognitive impairment or dementia: a scoping review

open access: yesFrontiers in Psychology
To date, the impact of cognitive therapies on patients with dementia and mild cognitive impairment (MCI) has been studied in terms of cognition, quality of life and activities of daily living rather than in the context of neuropsychiatric symptoms (NPS).
Beatriz Lara-Consuegra   +4 more
doaj   +1 more source

Music Therapy Techniques for Memory Stabilization in Diverse Dementias [PDF]

open access: yes, 2018
Music contains certain unmistakable healing properties pertaining specifically to the matured body and soul affected by various types of dementia. Music therapy aids in memory retention or the retarding of the loss of mental function as a result of ...
Shotts, Amanda
core   +1 more source

Materialising memories: exploring the stories of people with dementia through dress [PDF]

open access: yes, 2015
In this article, we use clothes as a tool for exploring the life stories and narratives of people with dementia, eliciting memories through the sensory and material dimensions of dress.
Buse, Christina E., Twigg, Julia
core   +4 more sources

The Microbiota Shapes Central Nervous System Myelination in Early Life

open access: yesAdvanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch   +13 more
wiley   +1 more source

An exploration of the utility of GSR in locating events from personal lifelogs for reflection [PDF]

open access: yes, 2010
Digital personal lifelogs (PLs) enable many artifacts from a person’s life to be automatically stored in a digital archive. These data sets can contain a wealth of potentially valuable information describing events from an individual’s life.
Jones, Gareth J.F., Kelly, Liadh
core  

A model of spirituality for ageing Muslims [PDF]

open access: yes, 2015
Spirituality’s influence on general well-being and its association with healthy ageing has been studied extensively. However, a different perspective has to be brought in when dealing with spirituality issues of ageing Muslims.
Mahjabeen Ahmad, Shamsul Khan
core   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

open access: yesAdvanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li   +11 more
wiley   +1 more source

Effects of Group Reminiscence Therapy on Disability of Nursing Home Residents in Mashhad –Iran 1390

open access: yesSālmand, 2012
Objectives: Examine the effects of group reminiscence therapy on disability of nursing home residents in Mashhad -Iran. Methods & Materials: In this semi-experimental study, 56 residents of nursing homes in Mashhad –Iran were selected by ...
Hadi Kooshyar   +5 more
doaj  

The Most Effective Treatment or Intervention for Treating Chinese Elderly Depression: a Literature Review [PDF]

open access: yes, 2014
Background: There is an increase in the percentage of Chinese elderly population with depression globally which may be contributed by financial stain, poor living conditions, and poor social support with friends and relatives, absence of carer and ...
Kaur, B, Lou, VW
core   +1 more source

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