Results 131 to 140 of about 363,124 (264)

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Label‐Free Myelin Fingerprinting: An Adult Human Post‐Mortem Brain Slice Platform via Coherent Anti‐Stokes Raman Spectroscopy

Advanced Science, EarlyView.
A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki, Jeroen P. Korterik, Femke Tjebbes, Geert J. Schenk, Herman L. Offerhaus, Antonio Luchicchi   +5 more
wiley   +1 more source

Benralizumab in Severe Eosinophilic Asthma: Toward Disease Control and Evolving Treatment Paradigms. [PDF]

J Inflamm Res
Maglio A, Vitale C, D'Auria LO, Longobardi V, Franzese A, Pelaia C, Pelaia G, Calabrese C, Vatrella A.   +8 more
europepmc   +1 more source

Remission [PDF]

, 2020
openaire   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Efficacy and Safety of Biological Agents in Giant Cell Arteritis: An Updated Meta-Analysis

Avicenna Journal of Medicine
Abdul Haseeb, Fabiha Athar, Hussain Abbas, Najia Sadiq, Faiza Naz, Erum Siddiqui, Osaid Ahmed, Umer Wamiq, Syed Ahmed Abbas Wasi, Hafsa Shuja, Bilal Aheed, Muhammad Ashir Shafique, Amna Sohail   +12 more
doaj   +1 more source

Treat-to-Target Strategy Achieves High Remission Rates with Sex Differences Attenuated Under Treat-to-Target Management in Rheumatoid Arthritis: A Longitudinal Analysis From the Rheumatoid Arthritis Saudi Database (RASD). [PDF]

Open Access Rheumatol
Almoallim HM, Bahlas SM, Bawazir Y, Hussein AH, Attia GM, Manasfi H, Bafadhl ZA, Bakhsh RA, Asiri AM, Ali AR, Alomair MM, Almalki H, Alsharaif M, Siddiqui MI, Alhazmi AS, Attar SM.   +15 more
europepmc   +1 more source

Spontaneous remission of hyperparathyroidism [PDF]

Nephrology Dialysis Transplantation, 2008
Pavlović, Draško, Brzac, Hrvojka Tomic
openaire   +4 more sources

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Complete blood count-derived inflammatory parameters in pediatric idiopathic uveitis. [PDF]

BMC Ophthalmol
Taşkın SN, Doğantan Ş, Ekici DY.
europepmc   +1 more source