Results 151 to 160 of about 492,944 (298)

Factors associated with failure to achieve remission and with relapse after remission in patients with major depressive disorder in the PERFORM study

open access: yes, 2017
Delphine Saragoussi,1 Maëlys Touya,2 Josep Maria Haro,3 Bengt Jönsson,4 Martin Knapp,5 Bastien Botrel,6 Ioana Florea,7 Henrik Loft,8 Benoît Rive9 1Real-World Evidence and Epidemiology, Lundbeck SAS, Issy-les-Moulineaux, France; 2Health ...
Touya M   +8 more
core  

Epitope characteristics of the remission group and the non-remission group before and after treatment (M0 and M6).

open access: yes
(A) Detection of numbers of epitopes recognized in the remission and non-remission groups using specific IgG. (B) Detection of numbers of epitopes recognized in the remission and non-remission groups using specific IgG4. (C) Use of IgG-specific to detect
Yuan Qin (260617)   +13 more
core   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

open access: yesAdvanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan   +7 more
wiley   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

open access: yesAdvanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao   +9 more
wiley   +1 more source

Clinical Remission Rates in Patients With Epithelial Ovarian Cancer Before and After the Onset of the COVID 19 Pandemic in an Integrated Healthcare Delivery System [PDF]

open access: yes
Amrita Mukherjee,1 Natalie Ayoub,2 Lanfang Xu,3 Kimberly L Cannavale,1 Alec D Gilfillan,1 Elizabeth A Szamreta,4 Matthew J Monberg,4 Melissa Hodeib,5 Chun R Chao1,6 1Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA,
Ayoub N   +8 more
core  

ROC analysis of serum anti-PLA2R antibodies between the remission and non-remission groups at initial diagnosis.

open access: yes
(A) ROC curve of serum anti-PLA2R-IgG and anti-PLA2R-IgG4 between the remission and non-remission groups. (B)ROC curve of serum eGFR+ anti-CTLD678 IgG4+ urinary protein between the remission and non-remission groups.
Yuan Qin (260617)   +13 more
core   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian   +8 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

open access: yesAdvanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng   +7 more
wiley   +1 more source

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