Results 151 to 160 of about 363,124 (264)

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Clinical and Behavioral Determinants of Type 2 Diabetes Remission After Bariatric Surgery: An Explainable Machine Learning Approach. [PDF]

J Clin Med
Algeffari M, Alhasson HF, Alharbi SS.
europepmc   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Distinct plasma protein profiles after long-term remission of Cushing's disease.

J Clin Endocrinol Metab
van der Vliet BF, Camilleri E, Paes T, Treep M, Dolezal N, Cordfunke RA, Drijfhout JW, Biermasz NR, Bos MHA, Cannegieter SC, Rosendaal FR, van Hylckama Vlieg A, Dekkers OM, Meijer OC, Pereira AM, Hofland LJ, Ruhaak LR, Klok FA, van Vlijmen BJM, Feelders RA.   +19 more
europepmc   +1 more source

Predictive factors for remission in pediatric Graves' disease treated with antithyroid drugs: a retrospective study. [PDF]

Arch Endocrinol Metab
Fernandes AJ, Gomes JP, Silva RAD, Portela M, Martins S, Marques O, Antunes A, Gomes MM.   +7 more
europepmc   +1 more source

Bridging Horizontal to Vertical Radiative Cooling

Advanced Science, EarlyView.
Radiative cooling materials are mature but only work facing the sky, confining them to rooftops. Instead of developing new ones, this system bridges existing horizontal coolers to vertical windows using blades outside the glass. On an occupied urban building, windows stay up to 1.4°C below air temperature while preserving daylight, outward views, and ...
Xiangyu Meng, Gan Huang
wiley   +1 more source

Sequential glofitamab and consolidative ASCT plus CAR-T therapy achieved durable remission in relapsed/refractory DLBCL. [PDF]

Blood Sci
Yan S, Wu J, Zhou M, Xiao Y.
europepmc   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Sustained Remission Following Limited Dupilumab Exposure in Refractory Eosinophilic Esophagitis. [PDF]

ACG Case Rep J
Kim DR, Bubelenyi A, Gupta M.
europepmc   +1 more source