Results 181 to 190 of about 20,963 (287)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Remnant cholesterol: an independent, dose-dependent risk factor for hyperuricemia in a normolipidemic chinese population. [PDF]

Front Endocrinol (Lausanne)
Xiong H, Ma F.
europepmc   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

The moderation effect of remnant cholesterol for linking cerebrospinal fluid interleukin 10 to blood pressure. [PDF]

Sci Prog
Yang X, Su L, Fan J, Chen Y, Yang Z, Kang Y, Luo X, Han X, Liu Y, Wang F.   +9 more
europepmc   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Longitudinal correlation between cumulative remnant cholesterol inflammatory index and incident diabetes. [PDF]

Diabetol Metab Syndr
Li Q, Gong L, Li H.
europepmc   +1 more source

Cd36 knockout mice are protected against lithogenic diet-induced gallstones [PDF]

, 2017
Abumrad, Nada A., Atabai, Kamran, Cifarelli, Vincenza, Clugston, Robin, Davidson, Nicholas O., Kennedy, Susan M., Khalifeh-Soltani, Amin, Newberry, Elizabeth P., Pietka, Terri, Xie, Yan   +9 more
core   +2 more sources

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Beyond cardiovascular disease: remnant cholesterol as a novel risk factor for osteoarthritis. [PDF]

Front Nutr
Xie R, Chen Z, Zhang G, Zhao W.
europepmc   +1 more source

Cholesterol in remnant-lipoproteins as measured by different methods [PDF]

Atherosclerosis, 2015
Peter P. Toth, W. Virgil Brown, Harold E. Bays, Joanne E. Tomassini, Colin Wang, Adam B. Polis, Andrew M. Tershakovec   +6 more
openaire   +1 more source