Results 171 to 180 of about 362,045 (252)

Higher remnant cholesterol to lymphocyte ratio is associated with vulnerable plaque features in acute coronary syndrome. [PDF]

Front Cardiovasc Med
Liu Y, Liu X, Yan W, Sun R, Yu Y, Chen A, Dong Z, Li X, Lv H.   +8 more
europepmc   +1 more source

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

Advanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li, Rui Fan, Kun Xie, Jiehua Zhong, Yitong Zhu, Tingting Ji, Yuanyuan Qin, Shijin Peng, Yu Zhang, Yuhang Guo, Tiange Zhang, Chunchen Liu, Bo Li, Lei Zheng, Ye Zhang, Xiaohui Yan   +15 more
wiley   +1 more source

Higher remnant cholesterol inflammatory index is associated with increased frailty risk in the UK Biobank. [PDF]

Front Nutr
Zhou Q, Liu M, Wang L, Wang P, Qin Y, Zhao M, Wanyan T, Yu J, Wan Y, Zhang Q, Sun C.   +10 more
europepmc   +1 more source

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

The Nonlinear Association Between Adipose Tissue Insulin Resistance and Remnant Cholesterol in Chinese Adults: A Cross-Sectional Study. [PDF]

J Cardiovasc Dev Dis
Cui R, Sun H, Yang M, Wang Y, Liu J, Wang G.   +5 more
europepmc   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Association of pre-pregnancy body mass index and first-trimester remnant cholesterol level with risk of large for gestational age. [PDF]

J Glob Health
Lin L, Zhang S, Lin J, Wang X.
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Interaction of hypertension and remnant cholesterol on arterial stiffness in Chinese middle-aged and elderly populations. [PDF]

Lipids Health Dis
Yi F, Zou X, Song W, Liu X, Ying Y, Xie Q, Gao Y.   +6 more
europepmc   +1 more source