Results 181 to 190 of about 20,723 (302)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Remnant Cholesterol as a Predictor of Target-Vessel Failure in Patients With In-Stent Restenosis. [PDF]

Rev Cardiovasc Med
Kong XH, Lv ZH, Wang YF, Sun YD, Xu T, You W, Meng PN, Wu XQ, Wu ZM, Jia HB, Ye F.   +10 more
europepmc   +1 more source

Cholesterol in remnant-lipoproteins as measured by different methods [PDF]

Atherosclerosis, 2015
Peter P. Toth, W. Virgil Brown, Harold E. Bays, Joanne E. Tomassini, Colin Wang, Adam B. Polis, Andrew M. Tershakovec   +6 more
openaire   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

The genetic basis of some adverse effects. The eudragene project [PDF]

, 2006
Asensio, P, Carvajal, A, Macias, D, McKeigue, P, Molokhia, M, Pytelova, V, Sainz, M, Salado, I, Urda, M   +8 more
core   +2 more sources

A Narrative Review of Remnant Cholesterol as an Independent Atherogenic Lipoprotein in Type 2 Diabetes: Pathophysiology and Clinical Implications. [PDF]

Ther Clin Risk Manag
Natsir RM, Halimah E, Diantini A, Levita J.   +3 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Remnant cholesterol: a risk stratification aid for coronary artery stenosis severity in patients with type 2 diabetes. [PDF]

Front Med (Lausanne)
Gan H, Gao K, Li Z, Zhang Y, Li L, Li Y, Guo H.   +6 more
europepmc   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Association of remnant cholesterol with cardiovascular events and mortality in biopsy-proven diabetic kidney disease. [PDF]

Front Endocrinol (Lausanne)
Hu Q, Chen L, Xing L, Xu Y, Xiong J, Tang Y.   +5 more
europepmc   +1 more source