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Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

open access: yesAdvanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen   +8 more
wiley   +1 more source

The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians. [PDF]

open access: yesBMC Med
Lin C   +15 more
europepmc   +1 more source
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Remnant cholesterol in patients admitted for acute coronary syndromes

European Journal of Preventive Cardiology, 2022
AbstractBackgroundRemnant cholesterol has been identified as one of leading lipid values associated with the incidence of coronary heart disease. There is scarce evidence on its distribution and prognostic value in acute coronary syndrome (ACS) patients.Methods and resultsWe included all consecutive patients admitted for ACS in two different centres ...
Alberto Cordero   +9 more
openaire   +5 more sources

Contribution of remnant cholesterol to cardiovascular risk

Journal of Internal Medicine, 2020
AbstractBackgroundRemnant cholesterol in triglyceride‐rich lipoproteins is associated observationally and genetic, causally with increased risk of atherosclerotic cardiovascular disease in healthy individuals.ObjectivesWe tested the hypothesis that an unmet medical need exists in individuals with high nonfasting remnant cholesterol and prior ...
A. Langsted   +2 more
openaire   +3 more sources

Remnant cholesterol, vascular risk, and prevention of atherosclerosis

Clínica e Investigación en Arteriosclerosis (English Edition), 2023
In patients who have achieved optimal LDL-C control, there remains a residual risk of atherothrombotic cardiovascular disease (ACVD) related to alterations in lipid metabolism, where alterations in triglyceride-rich lipoproteins and the cholesterol they contain, called remnant cholesterol, play a major role.
Xavier, Pintó   +3 more
openaire   +2 more sources

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