Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Investigation of Energy-Efficient Solutions for a Single-Family House Based on the 4E Idea in Poland
EnergiesThe paper analyses multi-variant energy simulations carried out in IDA ICE 4.8 software for a newly designed single-family building within the framework of the 4E Idea.
Piotr Ciuman +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
EnergiesDiffusers producing radial jets attached to the ceiling are most often used in ventilation and air conditioning systems. In building ventilation, the temperature of the jet supplying the air into the rooms is usually different to the surrounding air ...
Maria Hurnik
doaj +1 more source
Removal of Lead (II) from Aqueous Solution Using Cocopeat: An Investigation on the Isotherm and Kinetic [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2012 The aim of the present work was to investigate the ability of Cocopeat to remove of lead (II) from aqueous solutions. The effects of different parameters such as particle size, adsorbent dosage, pH, contact time, agitation speed and concentration on the ...
Abollfazl Shakeri +4 more
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Forced Migration Review, 2016 EU law and policy on non-removable irregular immigrants – such as unsuccessful asylum seekers who cannot be returned to their country of origin – have political and humanitarian consequences.
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Characterizing the removal of antibiotics in algal wastewater treatment ponds : a case study on tetracycline in HRAPs: a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Environmental Engineering at Massey University, Turitea Campus, Palmerston, New Zealand [PDF]
, 2016 Antibiotics are ubiquitous pollutants in wastewater, owing to their usefulness in both animal and human treatment. Antibiotic pollution is a growing concern because of the risk of encouraging antibiotic resistance in wastewater treatment (WWT) systems ...
Norvill, Zane
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