Results 91 to 100 of about 2,078,288 (303)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Pharmacokinetics of torasemide and its metabolites in end-stage renal disease [PDF]

, 1994
The pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v.
Schwab, A., Strutz, F., Müller, G. A., Krämer, Bernhard K., Braun, N., Risler, T.   +5 more
core   +1 more source

Early Identification of Sepsis-Induced Acute Kidney Injury by Using Monocyte Distribution Width, Red-Blood-Cell Distribution, and Neutrophil-to-Lymphocyte Ratio

Diagnostics
Sepsis-induced acute kidney injury (AKI) is a common complication in patients with severe illness and leads to increased risks of mortality and chronic kidney disease.
Yi-Hsiang Pan, Hung-Wei Tsai, Hui-An Lin, Ching-Yi Chen, Chun-Chieh Chao, Sheng-Feng Lin, Sen-Kuang Hou   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intra-Renal Angiotensin Levels Are Increased in High-Fructose Fed Rats in the Extracorporeal Renal Perfusion Model

Frontiers in Physiology, 2018
Overconsumption of fructose leads to metabolic syndrome as a result of hypertension, insulin resistance, and hyperlipidemia. In this study, the renal function of animals submitted to high fructose intake was analyzed from weaning to adulthood using in ...
Rodrigo Yokota, Fernanda Aparecida Ronchi, Fernanda Barrinha Fernandes, Zaira Palomino Jara, Rodolfo Mattar Rosa, Ana Paula de Oliveira Leite, Patricia Fiorino, Vera Farah, Nilberto Robson Falcão do Nascimento, Manassés C. Fonteles, Manassés C. Fonteles, Dulce Elena Casarini   +11 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lithium treatment reduces the renal kallikrein excretion rate [PDF]

, 1990
Lithium treatment reduces the renal kallikrein excretion rate. Lithium salts are widely used agents for the prophylactic treatment of affective disorders. Lithium salts may be associated with distal nephron dysfunction.
Marin-Grez, Marcos, Sauer, Heinrich, Gross, Peter, Reinhard, Caroline, Fink, Edwin   +4 more
core   +1 more source

Lúpus eritematoso sistêmico e tuberculose renal: descrição de nove Casos Systemic lupus erythematosus and renal tuberculosis: description of nine cases

Revista Brasileira de Reumatologia, 2008
OBJETIVO: O presente estudo tem por objetivo principal descrever uma série de nove casos de tuberculose (TB) renal em pacientes portadores de lúpus eritematoso sistêmico (LES) ocorridos em um período de seis anos em um hospital terciário do Nordeste ...
Daniela Cabral de Sousa, Marta Maria das Chagas Medeiros   +1 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction. [PDF]

, 2011
Innate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney disease is unclear.
Skuginna Veronika, Mantovani Alberto, S. Clauss, Heni Eka Susanti, R. Allam, Skuginna, Veronika, Clauss, Sebastian, Susanti, Heni Eka, Ramanjaneyulu Allam, H. E. Susanti, Hans-Joachim Anders, Christoph Römmele, Sebastian Clauss, M. Lech, Veronika Skuginna, Clauss Sebastian, Cecilia Garlanda, Lech, Maciej, Ryu, Mi, Lech Maciej, Garlanda Cecilia, C. Garlanda, Ryu Mi, Römmele, Christoph, Heni Eka, Mantovani, Alberto, Alberto Mantovani, Anders Hans-Joachim, Allam Ramanjaneyulu, Maciej Lech, Cecilia Garl, M. Ryu, Susanti Heni Eka, A. Mantovani, Anders, Hans-Joachim, Mi Ryu, Allam, Ramanjaneyulu, Römmele Christoph, C. Römmele, H. J. Anders, Garlanda, Cecilia, V. Skuginna   +41 more
core   +1 more source