Results 121 to 130 of about 4,080,709 (367)

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

CPNet: Cycle Prototype Network for Weakly-supervised 3D Renal Compartments Segmentation on CT Images [PDF]

open access: yesarXiv, 2021
Renal compartment segmentation on CT images targets on extracting the 3D structure of renal compartments from abdominal CTA images and is of great significance to the diagnosis and treatment for kidney diseases. However, due to the unclear compartment boundary, thin compartment structure and large anatomy variation of 3D kidney CT images, deep-learning
arxiv  

Effects of phlebotomy on the growth of ferric nitrilotriacetate-induced renal cell carcinoma. [PDF]

open access: yes, 2002
The ferric nitrilotriacetate-induced carcinogenesis model is unique in that reactive oxygen species-free radicals are involved in the carcinogenic process.
Fujisawa, Masayoshi   +5 more
core   +1 more source

Chronic renal failure after transplantation of a nonrenal organ.

open access: yesNew England Journal of Medicine, 2003
BACKGROUND Transplantation of nonrenal organs is often complicated by chronic renal disease with multifactorial causes. We conducted a population-based cohort analysis to evaluate the incidence of chronic renal failure, risk factors for it, and the ...
A. Ojo   +8 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

Renal structural image processing techniques: a systematic review

open access: yesRenal Failure, 2019
Background and objective: Renal disease, such as nephritis and nephropathy, is very harmful to human health. Accordingly, how to achieve early diagnosis and enhance treatment for kidney disorders would be the important lesion.
Shiva Asadzadeh   +4 more
doaj   +1 more source

Renal transplantation experience in Cairo University hospitals

open access: yesThe Egyptian Journal of Internal Medicine, 2016
Background Worldwide, the population treated with renal replacement therapy is increasing, representing ∼1.3 million patients who undergo dialysis and 400 000 patients who are alive with a kidney transplant.
Mohammed G Saadi   +2 more
doaj   +1 more source

Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms.

open access: yesCirculation Research, 2015
Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) hypertension.
J. Hall   +4 more
semanticscholar   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1508-1516, May 2025.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats

open access: yesJournal of Veterinary Internal Medicine, 2019
Background Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is increased in azotemic cats with chronic kidney disease (CKD) and predictive of the onset of azotemia in older cats.
Hannah J. Sargent   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy