Results 131 to 140 of about 4,080,709 (367)

SGLT2 Inhibitors and the Diabetic Kidney [PDF]

, 2016
Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. Blood glucose and blood pressure control reduce the risk of developing this complication; however, once DN is established, it is only possible to slow progression ...
Busetto, Luca, Fioretto, Paola, Rossato, Marco, Vettor, Roberto, Zambon, Alberto   +4 more
core   +1 more source

Renal control of calcium, phosphate, and magnesium homeostasis.

American Society of Nephrology. Clinical Journal, 2015
Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body
J. Blaine, M. Chonchol, M. Levi
semanticscholar   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus

Cells, 2019
Costimulatory molecules facilitate cross-talks among leukocytes via mutual stimulatory and inhibitory signalling, contributing to diverse immunological outcomes in normal physiological responses and pathological conditions.
Anselm Mak, Herbert Schwarz
doaj   +1 more source

Medication decision-making for patients with renal insufficiency in inpatient and outpatient care at a US Veterans Affairs Medical Centre: a qualitative, cognitive task analysis. [PDF]

, 2019
BackgroundMany studies identify factors that contribute to renal prescribing errors, but few examine how healthcare professionals (HCPs) detect and recover from an error or potential patient safety concern.
Arthur, Karen J, Diiulio, Julie B, Elkhadragy, Nervana, Glassman, Peter A, Ifeachor, Amanda P, Militello, Laura G, Russ, Alissa L, Weiner, Michael, Zillich, Alan J   +8 more
core   +1 more source

Toward Automation of the Supine Pressor Test for Preeclampsia [PDF]

, 2019
Preeclampsia leads to increased risk of morbidity and mortality for both mother and fetus. Most previous studies have largely neglected mechanical compression of the left renal vein by the gravid uterus as a potential mechanism.
Acharya, Aditi, Anderson, Jennifer L., Bennett, Rachel D., Bosinski, Brett M., Cox, Abigail D., Goergen, Craig J., Haas, David M., Ma, Jessica L., Qureshi, Hamna J., Reuter, David G., Wodicka, George R.   +10 more
core   +1 more source

Renal replacement therapy

Radiopaedia.org, 2018
Renal replacement therapies provide a substitute for the function of normal kidneys. Options include haemofiltration, haemodialysis, peritoneal dialysis, and renal transplantation. Haemofiltration is only used in the acute setting. Endocrine functions of
William G. Herrington, A. Chakera, Christopher A. O’Callaghan   +2 more
semanticscholar   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Incidental radiological finding of a renal tumour leading to the diagnosis of Birt-Hogg-Dubé syndrome [PDF]

, 2011
Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition characterised by benign tumours of the hair follicle, renal cancer, pulmonary cysts and spontaneous pneumothorax.
Dewilde, Dirk, HEYSE, CATHERINE, Lemmerling, Marc, Pauwels, Walter, Schreuer, Max, Verstraete, Koenraad   +5 more
core   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source