Results 141 to 150 of about 4,080,709 (367)

Interactions between renal vascular resistance and endothelium‐derived hyperpolarization in hypertensive rats in vivo

Physiological Reports, 2019
Endothelium derived signaling mechanisms play an important role in regulating vascular tone and endothelial dysfunction is often found in hypertension.
Søs U. Stannov, Jens Christian Brasen, Max Salomonsson, Niels‐Henrik Holstein‐Rathlou, Charlotte M. Sorensen   +4 more
doaj   +1 more source

Cross-stained Segmentation from Renal Biopsy Images Using Multi-level Adversarial Learning [PDF]

arXiv, 2020
Segmentation from renal pathological images is a key step in automatic analyzing the renal histological characteristics. However, the performance of models varies significantly in different types of stained datasets due to the appearance variations. In this paper, we design a robust and flexible model for cross-stained segmentation. It is a novel multi-
arxiv  

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK [PDF]

, 2015
To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and ...
ARDISSINO, ARDISSINO, ARONSON, BIRNBAUM, BLOMBERY, BOURHY, BOYCE, BURNENS, CARPENTER, CHANTREY, COWAN, DELL'ORCO, DICKINSON, EUBIG, FERRER, FISCHER, FOURNEL, GARCIA, GOLDFARB, GREENE, HENDRICKS, HERTZKE, HOLLOWAY, KAVANAGH, LI, MILFORD, MONAHAN, MOORE, MORRIS, MUNDAY, NORIS, PASS, REBAR, RENTKO, ROBY, ROTERMUND, RUGGENENTI, SALVADORI, SYKES, TANGEMAN, TARR, TARR, UCHIDA, VAN DEN INGH, VICTORIA, WAIKAR, WALKER   +46 more
core   +1 more source

Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction.

New England Journal of Medicine, 2004
BACKGROUND The presence of coexisting conditions has a substantial effect on the outcome of acute myocardial infarction. Renal failure is associated with one of the highest risks, but the influence of milder degrees of renal impairment is less well ...
N. Anavekar, J. McMurray, E. Velazquez, S. Solomon, L. Køber, J. Rouleau, H. White, R. Nordlander, A. Maggioni, K. Dickstein, S. Zelenkofske, J. Leimberger, R. Califf, M. Pfeffer   +13 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Tissue typing by unidirectional mixed lymphocyte culture. 3. The relationship of in vitro lymphocyte compatibility to renal allograft rejection [PDF]

, 1971
We applied unidirectional MLC test to renal allograft in dogs, and investigated the correlation between the growth rates of MLC reaction and the intensity of rejection of the kidney transplants or the postoperative renal function.
Tsunemitsu, Kensuke
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Prevalence of acute kidney injury in a population of hospitalized horses

Journal of Veterinary Internal Medicine, 2019
Background Hospital‐acquired acute kidney injury (AKI) in humans and dogs increases morbidity and nonsurvival. Azotemia at presentation has been associated with a poor outcome in horses; however, prevalence and consequences of hospital‐acquired AKI are ...
Victoria L. Savage, Celia M. Marr, Michael Bailey, Sarah Smith   +3 more
doaj   +1 more source

Epithelial to Mesenchymal Transition induces cell cycle arrest and parenchymal damage in renal fibrosis

Nature Network Boston, 2015
Kidney fibrosis is marked by an epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells (TECs). Here we find that, during renal fibrosis, TECs acquire a partial EMT program during which they remain associated with their basement membrane ...
S. Lovisa, Valerie S. LeBleu, B. Tampe, H. Sugimoto, Komal Vadnagara, Julienne L. Carstens, Chia-Chin Wu, Y. Hagos, B. Burckhardt, Tsvetelina Pentcheva-Hoang, Hersharan Nischal, J. Allison, M. Zeisberg, R. Kalluri   +13 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source