Results 271 to 280 of about 4,080,709 (367)

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

open access: yesAdvanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche   +16 more
wiley   +1 more source

In Situ‐Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)‐Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
In situ‐gelling poly(oligoethylene glycol methacrylate) (POEGMA)‐based hydrogels exhibit broad‐spectrum antibacterial activity against both gram‐positive and gram‐negative bacteria based on the dual covalent attachment of quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP) into the hydrogel networks, enabling effective in vivo burn ...
Fei Xu   +8 more
wiley   +1 more source

Synthetic Bilirubin‐Based Nanomedicine Protects Against Renal Ischemia/Reperfusion Injury Through Antioxidant and Immune‐Modulating Activity

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan   +13 more
wiley   +1 more source

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