Results 111 to 120 of about 373,614 (309)

Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance

Advanced Healthcare Materials, EarlyView.
Single‐chain nanoparticles have been proposed as drug delivery carriers, but adding a tail can significantly enhance their performance. This was demonstrated using a tadpole‐like structure comprising a head prepared from a UV‐crosslinked fructose‐based glycopolymer capable of targeting GLUT receptors, combined with a PEG‐based tail. Compared with other
Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel   +6 more
wiley   +1 more source

Increased plasma viscosity as a reason for inappropriate erythropoietin formation

, 1993
The aim of this study was to examine whether altered plasma viscosity could contribute to the inappropriately low production rate of erythropoietin (EPO) observed in patients suffering from hypergammaglobulinemias associated with multiple myeloma or ...
A Zimmermann, K H Götz, Ratcliffe, P. J., Ratcliffe, Peter, Reinhart, WH, Götz, Karlheinz, Hamann, M., Götz, KH, M Hamann, A Kurtz, A Singh, Kurtz, A, Reinhart, W. H., Singh, A., Zimmermann, A., Kurtz, Armin, K U Eckardt, Hamann, M, Singh, A, Eckardt, KU, P J Ratcliffe, W H Reinhart, Zimmermann, A, Eckardt, Kai-Uwe   +23 more
core   +1 more source

Circadian variation in renal blood flow and kidney function in healthy volunteers monitored using non-invasive magnetic resonance imaging

, 2020
Circadian regulation of kidney function is involved in maintaining whole-body homeostasis and dysfunctional circadian rhythm can potentially be involved in disease development. Magnetic Resonance Imaging (MRI)provides reliable and reproducible repetitive
Hansell, Peter, Buchanan, Charlotte, Palm, Fredrik, Hansell, Peter,, Liss, Per,, Francis, Susan, Eckerbom, Per, Weis, Jan, Eckerbom, Per,, Palm, Fredrik,, Weis, Jan,, Cox, Eleanor, Liss, Per   +12 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

A blood-perfusion flowmeter

, 1975
Includes bibliographical references.A variety of methods have been used for measuring blood flow in large vessels. However, almost all of these methods are unsuitable for measuring perfusion flow in tissue.
Hughes, Timothy John
core  

Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs

, 2006
Low cardiac output impairs the hepatic arterial buffer response (HABR). Whether this is due to low abdominal blood flow per se is not known. Dobutamine is commonly used to increase cardiac output, and it may further modify hepatosplanchnic and renal ...
Widmer, Matthias K, Juerg Schmidli, Matthias K. Widmer, Jukka Takala, Brander, Lukas, Takala, Jukka, Stephan M. Jakob, Savolainen, Hannu, Hannu Savolainen, Jakob, Stephan M, Schmidli, Juerg, Lukas Brander, Knuesel, Rafael, Rafael Knuesel   +13 more
core   +1 more source

Low-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment

Frontiers in Pharmacology
BackgroundNeurostimulation is an emerging treatment for conditions like hypertension. The renal nerves, comprising sensory afferent and sympathetic efferent fibers, are crucial for blood pressure (BP) regulation.
Ibrahim M. Salman, Omar Z. Ameer, Sarah F. Hassan, Arun Sridhar, Yee-Hsee Hsieh, Stephen J. Lewis, Stephen J. Lewis   +6 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Technique for the simultaneous measurement of renal ATP, blood flow and pH in a large animal model of septic shock

, 2007
BACKGROUND: Simultaneous measurement of renal blood flow, renal ATP, renal pH and mean arterial pressure (MAP) might help investigators understand the mechanisms responsible for acute renal failure (ARF) in sepsis.
Langenberg, Christoph, Wan, Li, Pell, Gaby S., Bolomo, Rinaldo A., May, Clive, Wellard, R. Mark, Jackson, Graeme, Williams, John   +7 more
core