Results 141 to 150 of about 576,676 (310)

Assessing Renal Microvascular Reactivity by Laser Speckle-Contrast Imaging in Angiotensin-II-Treated Mice

International Journal of Nephrology and Renovascular Disease, 2020
Nicolas Mottard,1,2 Dan E Berkowitz,1,3 Lakshmi Santhanam1,3 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Department of Anesthesiology and Critical Care, Clinique de la ...
Mottard N, Berkowitz DE, Santhanam L
doaj  

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Scientific Reports
Non-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine.
Yusuf O. Cakmak, Prashanna Khwaounjoo, Joseph Pangilinan, Innes K. Wise, Chris Burrows, Pranish Kolakshyapati, Zoe Williams, Paul Bannon   +7 more
doaj   +1 more source

Quantitative analysis of renal blood flow during thoracic endovascular aortic repair in type B aortic dissection using syngo iFlow. [PDF]

Quant Imaging Med Surg, 2021
Fang K, Zhao J, Luo M, Xue Y, Wang H, Ye L, Zhang X, Zheng L, Shu C.   +8 more
europepmc   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Features arterial renal blood flow in acute pancreatitis

Кубанский научный медицинский вестник, 2015
Doppler ultrasound dynamic in interlobar arteries allows indirectly assess arterial blood flow component intraorganic, state microvasculature of kidneys when they are damaged on the background of endotoxemia, as well as state of the peripheral vascular ...
Yu. S. Vinnik, E. V. Repina, E. V. Serova, M. A. Makarkina, D. Yu. Lopatin, V. P. Pustovalov   +5 more
doaj  

Ex Vivo Simultaneous H₂¹⁵O Positron Emission Tomography and Magnetic Resonance Imaging of Porcine Kidneys—A Feasibility Study

Journal of Imaging
The aim was to establish combined H215O PET/MRI during ex vivo normothermic machine perfusion (NMP) of isolated porcine kidneys. We examined whether changes in renal arterial blood flow (RABF) are accompanied by changes of a similar magnitude in renal ...
Maibritt Meldgaard Arildsen, Christian Østergaard Mariager, Christoffer Vase Overgaard, Thomas Vorre, Martin Bøjesen, Niels Moeslund, Aage Kristian Olsen Alstrup, Lars Poulsen Tolbod, Mikkel Holm Vendelbo, Steffen Ringgaard, Michael Pedersen, Niels Henrik Buus   +11 more
doaj   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Focus on renal blood flow in mechanically ventilated patients with SARS-CoV-2: a prospective pilot study. [PDF]

J Clin Monit Comput, 2022
Fogagnolo A, Grasso S, Dres M, Gesualdo L, Murgolo F, Morelli E, Ottaviani I, Marangoni E, Volta CA, Spadaro S.   +9 more
europepmc   +1 more source