Results 41 to 50 of about 368,090 (264)
Visualization of the intrarenal distribution of capillary blood flow
Physiological Reports, 2019 This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions.
Letao Fan +6 more
doaj +1 more source
Perspectives on Renal Blood Flow Autoregulation
Experimental Biology and Medicine, 1991 ConclusionThere is a continuing debate in regard to the relative contribution of TGF and myogenic mechanisms in the control autoregulation in the kidney. Much of the controversy, relating to the relative importance of each mechanism can possibly be explained simply by considering the species from which evidence is derived. Differences in autoregulatory
D M, Pollock, R O, Banks
openaire +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
International Journal of Nephrology and Renovascular Disease, 2017 Sinny Delacroix,1,2 Ramesh G Chokka,1,3 Adam J Nelson,1,2 Dennis T Wong,4 Samuel Sidharta,1,2 Stephen M Pederson,5 Adil Rajwani,1,2 Joanne Nimmo,1,2 Karen S Teo,1,2 Stephen G Worthley1,2 1Cardiovascular Research Centre, Royal Adelaide Hospital ...
Delacroix S +9 more
doaj
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Linchuang shenzangbing zazhiObjective To explore the value of blood flow resistance index of both kidneys plus visceral adipose tissue-derived serine protease inhibitor (Vaspin) in predicting renal function in patients with type 2 diabetic nephropathy (T2DN).
Wen-qi Lu +5 more
doaj +1 more source
Kidney International Reports, 2017 Chronic kidney disease (CKD) is known to be associated with reduced renal blood flow. However, data in humans are limited to date. Methods: In this study, noninvasive arterial spin labeling magnetic resonance imaging data were acquired in 33 patients ...
Lu-Ping Li +7 more
doaj +1 more source
Heliyon, 2020 Objectives: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive (H:N) ratio in the renal bed compared with the total peripheral bed in conscious ...
Makhala M. Khammy +2 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source