Results 61 to 70 of about 6,126,512 (255)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Value of blood flow resistance index plus Vaspin in predicting renal function in patients with type 2 diabetic nephropathy

Linchuang shenzangbing zazhi
Objective To explore the value of blood flow resistance index of both kidneys plus visceral adipose tissue-derived serine protease inhibitor (Vaspin) in predicting renal function in patients with type 2 diabetic nephropathy (T2DN).
Wen-qi Lu, Yan-ru Zhao, Huan-di Li, Xin-na Fan, Ping Li, Kun Wei   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. [PDF]

, 2014
Resistant hypertension continues to pose a major challenge to clinicians worldwide and has serious implications for patients who are at increased risk of cardiovascular morbidity and mortality with this diagnosis.
Matson, M, Williams, B, Paton, JF, Kapil, Vikas, Moss, J, Simpson, Iain, Knight, Charles, Poulter, Neil, Poulter, N, Collier, David, de Belder, Mark A, Caulfield, Mark J, Matson, Matthew, Simpson, I, Cleveland, Trevor, Deanfield, John, Lobo, MD, de Belder, MA, Williams, Bryan, Lobo, Melvin D, Moss, Jonathan, Caulfield, MJ, Kapil, V, Knight, C, Paton, Julian F R, Dasgupta, I, Paton, JFR, Deanfield, J, ?, ?, Cleveland, T, Collier, D, Dasgupta, Indranil   +31 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Haemodynamic responses to heat stress and hypohydration in resting and exercising humans: Implications for the regulation of skeletal muscle blood flow [PDF]

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Heat stress-induced hyperthermia and exercise-induced hypohydration are associated with marked alterations in limb and systemic haemodynamics in humans ...
Pearson, James
core   +5 more sources

Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature

Heliyon, 2020
Objectives: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive (H:N) ratio in the renal bed compared with the total peripheral bed in conscious ...
Makhala M. Khammy, James A. Angus, Christine E. Wright   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Renal hemodynamics disturbances and microalbuminuria in young patients with arterial hypertension

Кардиоваскулярная терапия и профилактика, 2005
Aim. To identify the first clinical signs of renal pathology in young patients (under 35) with initial stages of arterial hypertension (AH). Material and methods. Fifty-seven men with Stage I-II AH, aged 15-35, were examined.
I. G. Fomina, E. N. Gavrilova, N. E. Gaidamakina, T. A. Dyakova, D. A. Zateyshchikova   +4 more
doaj