Results 61 to 70 of about 373,614 (309)
Perspectives on Renal Blood Flow Autoregulation
Experimental Biology and Medicine, 1991 ConclusionThere is a continuing debate in regard to the relative contribution of TGF and myogenic mechanisms in the control autoregulation in the kidney. Much of the controversy, relating to the relative importance of each mechanism can possibly be explained simply by considering the species from which evidence is derived. Differences in autoregulatory
D M, Pollock, R O, Banks
openaire +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension [PDF]
, 2013 In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB) produces a rapid and pronounced fall in both arterial pressure and renal sympathetic nerve activity (RSA).
Hendy, Emma B +7 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Iliorenal periscope graft to maintain blood flow to accessory renal artery [PDF]
, 2015 Parallel endografts such as “chimney” and “periscope” are being increasingly used to maintain blood flow to visceral and supra-aortic branches in patients with different aortic disorders.
Emrah Uguz +3 more
core +1 more source
Linchuang shenzangbing zazhiObjective To explore the value of blood flow resistance index of both kidneys plus visceral adipose tissue-derived serine protease inhibitor (Vaspin) in predicting renal function in patients with type 2 diabetic nephropathy (T2DN).
Wen-qi Lu +5 more
doaj +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Assessment of control and performance of biomedical systems [PDF]
, 2010 Introduction: In biomedical systems repeated measurements are often collected, thus presenting a statistical challenge due to high temporal correlation. This research investigates the potential utility of two distinct statistical methodologies in their ...
Harris, Katie
core
Heliyon, 2020 Objectives: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive (H:N) ratio in the renal bed compared with the total peripheral bed in conscious ...
Makhala M. Khammy +2 more
doaj +1 more source