Results 1 to 10 of about 577,818 (354)
Nature Reviews Disease Primers, 2017 Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and accounts for >90% of cancers in the kidney. The disease encompasses >10 histological and molecular subtypes, of which clear cell RCC (ccRCC) is most common and accounts for most cancer-related deaths. Although somatic VHL mutations have been described for some time, more-
Hsieh, James J. +8 more
openaire +4 more sources
Small bowel intussusception from renal cell carcinoma metastasis : a case report and review of the literature [PDF]
, 2016 Background: Renal cell carcinoma is the most frequent malignant neoplasia of the kidney accounting for 90 % of all renal solid tumors. Metastases from renal cell carcinoma are rarely located in the small bowel and generally their clinical presentation ...
Bellio, Gabriele +5 more
core +1 more source
Immune checkpoint inhibitors in renal cell carcinoma [PDF]
, 2017 The immune system has long been known to play a critical role in the body's defence against cancer, and there have been multiple attempts to harness it for therapeutic gain.
Jones, Robert J., Ross, Kirsty
core +1 more source
Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies [PDF]
, 2019 A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the
Meierhofer, David, Xiao, Yi
core +2 more sources
Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab. [PDF]
, 2014 PurposeWe hypothesized that bortezomib, an agent that suppresses HIF-1α transcriptional activity, when combined with bevacizumab, would obviate the HIF-1α resistance pathway.
Amin, Hesham M +16 more
core +2 more sources
Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma
Tumor Biology, 2017 Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer–testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal ...
Yibo Hua +12 more
doaj +1 more source
Case of hereditary papillary renal cell carcinoma [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2012 Renal cell carcinoma is the most common type of renal malignancy and it originates from the renal tubular epithelium. Due to the diversity in the histopathological and molecular characteristics, it is typically subclassified into five different ...
Sadaf Mustafa +3 more
doaj +1 more source
Oncogenic microRNAs characterization in clear cell renal cell carcinoma [PDF]
, 2015 A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of
BELLISSIMO, TERESA +8 more
core +2 more sources
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the effect of long-chain non-coding RNA FILNC1 targeting c-Myc expression on the biological behavior of renal cell carcinoma. Methods qPCR was used to detect the expression of FILNC1 in renal cell carcinoma tissues and different ...
ZHANG Xiaofang, ZHAO Ying, LI Qi
doaj +1 more source
Atraumatic Ruptured Giant Renal Tumor
The Annals of African Surgery, 2020 Massive hemoperitoneum due to spontaneous rupture of renal cell carcinoma is a rare presentation during emergency laparotomy. A 60-year-old female patient presented with severe abdominal pain, nausea, vomiting and abdominal distension.
Gezahen Negusse Ayane, Khutsafalo Kadimo
doaj