Results 31 to 40 of about 1,282,079 (202)

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline

Journal of Clinical Oncology, 2022
PURPOSE To provide recommendations for the management of patients with metastatic clear cell renal cell carcinoma (ccRCC). METHODS An Expert Panel conducted a systematic literature review to obtain evidence to guide treatment recommendations. RESULTS The
W. Rathmell, R. Rumble, P. V. Van Veldhuizen, H. Al-Ahmadie, H. Emamekhoo, R. Hauke, A. Louie, M. Milowsky, A. Molina, T. Rose, S. Siva, Nicholas G Zaorsky, Tian Zhang, R. Qamar, Terry M Kungel, B. Lewis, E. Singer   +16 more
semanticscholar   +1 more source

Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma

Tumor Biology, 2017
Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer–testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal ...
Yibo Hua, Chao Liang, Jundong Zhu, Chenkui Miao, Yajie Yu, Aimin Xu, Jianzhong Zhang, Pu Li, Shuang Li, Meiling Bao, Jie Yang, Chao Qin, Zengjun Wang   +12 more
doaj   +1 more source

Treatment Landscape of Renal Cell Carcinoma

Current Treatment Options in Oncology, 2023
The treatment landscape of renal cell carcinoma (RCC) has evolved significantly over the past three decades. Active surveillance and tumor ablation are alternatives to extirpative therapy in appropriately selected patients.
Yu-Wei Chen, Luke L. Wang, J. Panian, S. Dhanji, I. Derweesh, B. Rose, Aditya Bagrodia, R. R. Mckay   +7 more
semanticscholar   +1 more source

COMPREHENSIVE MOLECULAR CHARACTERIZATION OF CLEAR CELL RENAL CELL CARCINOMA

Nature, 2013
Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, PBRM1).
The Cancer Genome Atlas Research Network
semanticscholar   +1 more source

The long noncoding RNA urothelial carcinoma-associated 1 overexpression as a poor prognostic biomarker in clear cell renal cell carcinoma

Tumor Biology, 2017
Long noncoding RNA urothelial carcinoma-associated 1 has previously played important roles in cancer. However, its role is still unknown in clear cell renal cell carcinoma.
Yang Wang, Wen Gao, Jiali Xu, Yizhi Zhu, Lingxiang Liu   +4 more
doaj   +1 more source

Progressive immune dysfunction with advancing disease stage in renal cell carcinoma

Cancer Cell, 2021
SUMMARY The tumor immune microenvironment plays a critical role in cancer progression and response to immunotherapy in clear cell renal cell carcinoma (ccRCC), yet the composition and phenotypic states of immune cells in this tumor are incompletely ...
D. Braun, Kelly Street, K. Burke, D. Cookmeyer, Thomas Denize, C. B. Pedersen, S. Gohil, N. Schindler, Lucas Pomerance, L. Hirsch, Z. Bakouny, Yue Hou, J. Forman, Teddy Huang, Shuqiang Li, Ang Cui, D. Keskin, J. Steinharter, G. Bouchard, Maxine Sun, E. Pimenta, Wenxin Xu, K. Mahoney, B. McGregor, M. Hirsch, Steven L. Chang, K. Livak, D. McDermott, S. Shukla, L. Olsen, S. Signoretti, A. Sharpe, R. Irizarry, T. Choueiri, Catherine J. Wu   +34 more
semanticscholar   +1 more source

Atraumatic Ruptured Giant Renal Tumor

The Annals of African Surgery, 2020
Massive hemoperitoneum due to spontaneous rupture of renal cell carcinoma is a rare presentation during emergency laparotomy. A 60-year-old female patient presented with severe abdominal pain, nausea, vomiting and abdominal distension.
Gezahen Negusse Ayane, Khutsafalo Kadimo
doaj  

Effect of Long-chain Non-coding RNA FILNC1 Targeting c-Myc Expression on Biological Behavior of Renal Cell Carcinoma

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the effect of long-chain non-coding RNA FILNC1 targeting c-Myc expression on the biological behavior of renal cell carcinoma. Methods qPCR was used to detect the expression of FILNC1 in renal cell carcinoma tissues and different ...
ZHANG Xiaofang, ZHAO Ying, LI Qi
doaj   +1 more source

Conditional survival and long‐term efficacy with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma

Cancer, 2022
Conditional survival estimates provide critical prognostic information for patients with advanced renal cell carcinoma (aRCC). Efficacy, safety, and conditional survival outcomes were assessed in CheckMate 214 (ClinicalTrials.gov identifier NCT02231749 ...
R. Motzer, D. McDermott, B. Escudier, M. Burotto, T. Choueiri, H. Hammers, P. Barthélémy, E. Plimack, C. Porta, S. George, T. Powles, F. Donskov, H. Gurney, C. Kollmannsberger, M. Grimm, C. Barrios, Y. Tomita, D. Castellano, V. Grünwald, B. Rini, M. McHenry, Chung-Wei Lee, Jennifer McCarthy, F. Ejzykowicz, N. Tannir   +24 more
semanticscholar   +1 more source

European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update.

European Urology, 2019
CONTEXT The European Association of Urology Renal Cell Carcinoma (RCC) Guideline Panel has prepared evidence-based guidelines and recommendations for the management of RCC. OBJECTIVE To provide an updated RCC guideline based on standardised methodology
B. Ljungberg, L. Albiges, Y. Abu-Ghanem, K. Bensalah, S. Dabestani, S. Fernandez-Pello, R. Giles, F. Hofmann, M. Hora, M. Kuczyk, T. Kuusk, T. Lam, L. Marconi, A. Merseburger, T. Powles, M. Staehler, R. Tahbaz, A. Volpe, A. Bex   +18 more
semanticscholar   +1 more source