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Overview of clear cell renal cell carcinoma: from mechanisms to clinical [PDF]

Frontiers in Medicine
Clear cell renal cell carcinoma is the most common histological subtype of kidney cancer, and its development is often related to mutations in the VHL gene. Inactivation of the VHL gene leads to accumulation of HIF-2α.
Han Yang, Xingda Zhang, Qingming Ji, Xia Sheng   +3 more
doaj   +2 more sources

LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway

Cells, 2022
ccRCC is highly immunogenic, yet its underlying immune-related molecular mechanisms are unknown. Leukotriene B4 Receptor 1 (LTB4R), a novel immune-related gene associated in our previous research with the prognosis of ccRCC patients, has been found in ...
Xiao Zhang, Huahui Wu, Xin Yan, Jiajun Ma, Zhao Chen   +4 more
doaj   +1 more source

Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma

Frontiers in Genetics, 2023
Background: Cytoskeleton-associated protein 2-like protein (CKAP2L) is thought to promote the progression of glioma, breast cancer, and ovarian cancer. However, the role of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma
Zhi Liu, Jun Zhang, Deyun Shen, Xuechun Hu, Zongpan Ke, I Nyoman Ehrich Lister, Bungaran Sihombing   +6 more
doaj   +1 more source

Genetics and Tumor Microenvironment of Renal Cell Carcinoma

Société Internationale d’Urologie Journal, 2022
Renal cell carcinoma is a diverse group of diseases that can be distinguished by distinct histopathologic and genomic features. In this comprehensive review, we highlight recent advancements in our understanding of the genetic and microenvironmental ...
Sari Khaleel, Christopher Ricketts, W. Marston Linehan, Mark Ball, Brandon Manley, Samra Turajilic, James Brugarolas, Ari Hakimi   +7 more
doaj   +1 more source

Renal Lipid Metabolism Abnormalities in Obesity and Clear Cell Renal Cell Carcinoma

Metabolites, 2021
Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits.
Ion Alexandru Bobulescu, Laurentiu M. Pop, Chinnadurai Mani, Kala Turner, Christian Rivera, Sabiha Khatoon, Subash Kairamkonda, Raquibul Hannan, Komaraiah Palle   +8 more
doaj   +1 more source

Role of tumor-derived exosomes in metastasis, drug resistance and diagnosis of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
Renal cancer is one of the most extensively studied human tumors today, with clear cell renal cell carcinoma accounting for approximately 80% of all cases.
Tiancheng Jiang, Tiancheng Jiang, Zepeng Zhu, Zepeng Zhu, Jiawei Zhang, Jiawei Zhang, Ming Chen, Ming Chen, Shuqiu Chen, Shuqiu Chen   +9 more
doaj   +1 more source

Ipsilateral synchronous clear and papillary renal cell carcinoma: A case report and review of the literature

Urology Case Reports, 2018
Clear cell renal cell carcinoma and papillary renal cell carcinoma are the most common types of renal tumors. However, coexistence of both tumors in the same kidney is a rare condition.We report a 56-year old male who was found to have ipsilateral ...
Muna Alhusban, Sohaib Alhamss, Bayan Alzumaili, Ali Al-Daghmin   +3 more
doaj   +1 more source

Immune classification of clear cell renal cell carcinoma

Scientific Reports, 2021
Since the outcome of treatments, particularly immunotherapeutic interventions, depends on the tumor immune micro-environment (TIM), several experimental and computational tools such as flow cytometry, immunohistochemistry, and digital cytometry have been
Sumeyye Su, Shaya Akbarinejad, Leili Shahriyari   +2 more
doaj   +1 more source

Cellular milieu in clear cell renal cell carcinoma

Frontiers in Oncology, 2022
Clear cell renal cell carcinoma (ccRCC) is globally the most prevalent renal cancer. The cells of origin in ccRCC have been identified as proximal tubular epithelial cells (PTEC); however, the transcriptomic pathways resulting in the transition from ...
Arti M. Raghubar, Arti M. Raghubar, Arti M. Raghubar, Arti M. Raghubar, Arti M. Raghubar, Matthew J. Roberts, Matthew J. Roberts, Matthew J. Roberts, Matthew J. Roberts, Simon Wood, Simon Wood, Helen G. Healy, Helen G. Healy, Helen G. Healy, Andrew J. Kassianos, Andrew J. Kassianos, Andrew J. Kassianos, Andrew J. Mallett, Andrew J. Mallett, Andrew J. Mallett, Andrew J. Mallett   +20 more
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Metabolic reprogramming of clear cell renal cell carcinoma

Frontiers in Endocrinology, 2023
Clear cell renal cell carcinoma (ccRCC) is a malignancy that exhibits metabolic reprogramming as a result of genetic mutations. This reprogramming accommodates the energy and anabolic needs of the cancer cells, leading to changes in glucose, lipid, and ...
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou   +3 more
doaj   +1 more source