Results 61 to 70 of about 1,140,223 (331)

Genomic and Pathological Characterization of Multiple Renal Cell Carcinoma Regions in Patient With Tuberous Sclerosis Complex: A Case Report

Frontiers in Oncology, 2021
Tuberous sclerosis complex is a genetic disorder characterized by facial angiofibromas, intellectual disability, epilepsy, and tumor formation in multiple organs, including the kidney.
Tetsuya Yamamoto, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Shinichiro Fukuhara, Hiroshi Kiuchi, Ryoichi Imamura, Naokazu Ibuki, Kazuma Kiyotani, Masako Kurashige, Eichi Morii, Kazutoshi Fujita, Norio Nonomura, Motohide Uemura   +14 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Pazopanib versus sunitinib in metastatic renal-cell carcinoma.

New England Journal of Medicine, 2013
BACKGROUND Pazopanib and sunitinib provided a progression-free survival benefit, as compared with placebo or interferon, in previous phase 3 studies involving patients with metastatic renal-cell carcinoma.
R. Motzer, Thomas E. Hutson, D. Cella, J. Reeves, R. Hawkins, Jun Guo, P. Nathan, M. Staehler, P. de Souza, J. Merchan, E. Boleti, K. Fife, Jie Jin, Robert J. Jones, H. Uemura, U. de Giorgi, U. Harmenberg, Jinwan Wang, C. Sternberg, K. Deen, L. McCann, M. Hackshaw, R. Crescenzo, L. Pandite, T. Choueiri   +24 more
semanticscholar   +1 more source

Hereditary leiomyomatosis and renal cell carcinoma

International Journal of Nephrology and Renovascular Disease, 2014
Laura S Schmidt,1,2 W Marston Linehan11Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; 2Basic Science Program, Leidos Biomedical Research Inc., Frederick National ...
Schmidt LS, Linehan WM
doaj  

Single-cell profiling of the microenvironment in human bone metastatic renal cell carcinoma

Communications Biology
Bone metastasis is of common occurrence in renal cell carcinoma with poor prognosis, but no optimal treatment approach has been established for bone metastatic renal cell carcinoma.
Fen Ma, Shuoer Wang, Lun Xu, Wending Huang, Guohai Shi, Zhengwang Sun, Weiluo Cai, Zhiqiang Wu, Yiming Huang, Juan Meng, Yining Sun, Meng Fang, Mo Cheng, Yingzheng Ji, Tu Hu, Yunkui Zhang, Bingxin Gu, Jiwei Zhang, Shaoli Song, Yidi Sun, Wangjun Yan   +20 more
doaj   +1 more source

Exosome in renal cell carcinoma progression and implications for targeted therapy

Frontiers in Oncology
Renal cell carcinoma is a urological malignancy with a high metastatic rate, while targeted therapy for renal cell carcinoma still has much room for improvement.
Xinwei Li, Xinwei Li, Wen Xiao, Wen Xiao, Hongmei Yang, Xiaoping Zhang, Xiaoping Zhang, Xiaoping Zhang   +7 more
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Clinicopathologic features of renal cell carcinomas seen at the Aga Khan University Hospital in Kenya

Frontiers in Medicine, 2022
IntroductionKidney cancer accounted for 1. 8% of global cancer deaths according to Globocan 2020 estimates, with most of these being renal cell carcinomas. Lower rates of renal cell carcinoma are reported for Africa and these are expected to change for a
Anderson Mutuiri, Samuel Gakinya
doaj   +1 more source

The expression of RNA-binding protein RBM38 decreased in renal cell carcinoma and represses renal cancer cell proliferation, migration, and invasion

Tumor Biology, 2017
RBM38, a member of RNA recognition motif family of RNA-binding proteins, can regulate the expression of diverse targets by influencing their messenger RNA stability and play a vital role in cancer development.
Wen Huang, Xiao-Long Wei, WeiWei Ni, Mengda Cao, Ling Meng, Haiwei Yang   +5 more
doaj   +1 more source