Results 101 to 110 of about 2,405,382 (374)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Case report: full recovery from dialysis-requiring renal failure after surgical repair of a completely occluded renal artery in a patient with a single kidney

BMC Nephrology
Introduction Renal infarction is an extremely rare condition occurring in the context of structural or functional cardiac abnormalities, renal artery injury or coagulative syndromes.
Marta Kantauskaite, Klaus Grabitz, Lars Christian Rump, Sebastian Alexander Potthoff   +3 more
doaj   +1 more source

Renal medullary circulation: Hormonal control

Kidney International, 1990
It is now becoming apparent that the medullary circulation in the kidney can be regulated separately from overall renal blood flow. This characteristic of the medullary circulation plays an important role in the kidney's ability to excrete a dilute or concentrated urine in concert with changes in water and sodium transport in the distal nephron ...
Chou, Shyan Yih, Porush, Jerome G., Faubert, Pierre F.   +2 more
openaire   +2 more sources

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension [PDF]

, 2013
In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB) produces a rapid and pronounced fall in both arterial pressure and renal sympathetic nerve activity (RSA).
Abdala, Ana P, Hendy, Emma B, Marvar, Paul, McBryde, Fiona D, Moraes, Davi J A, Paton, Julian F R, Pijacka, Wioletta, Sobotka, Paul A   +7 more
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Transcatheter Aortic Valve Implantation in Dialysis Patients [PDF]

, 2012
Background/Aims: Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option for high-risk patients. However, dialysis patients were excluded from all previous studies.
Baglin A, Braun J, Bryg RJ, Christian Kupatt, Cribier A, Edwards FH, Gerhard Steinbeck, Herzog CA, Iung B, Leon MB, London GM, Lucke JC, Maher ER, Matthias Wessely, Michael Fischereder, Philipp Lange, Rodes-Cabau J, Simon Rau, Smith CR, Stinebaugh J, Straumann E, Tanaka K, Ulf Schönermarck, Urena P, Varadarajan P, Varma R   +25 more
core   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Visualization of the intrarenal distribution of capillary blood flow

Physiological Reports, 2019
This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions.
Letao Fan, Shaoxun Wang, Xiaochen He, Ezekiel Gonzalez‐Fernandez, Claude Lechene, Fan Fan, Richard J. Roman   +6 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Deterioration in Renal Function in Patients With a Fontan Circulation and Association With Mortality

JACC: Advances
Background: Renal dysfunction is a well-established risk factor in cardiovascular disease, but little is known about the prevalence and factors associated with deterioration in renal function in patients with a Fontan circulation. Objectives: The purpose
Gaston van Hassel, MD, Dion Groothof, BSc, Johannes M. Douwes, MD, PhD, Elke S. Hoendermis, MD, PhD, Eryn T. Liem, MD, PhD, Tineke P. Willems, MD, PhD, Tjark Ebels, MD, PhD, Adriaan A. Voors, MD, PhD, Stephan J.L. Bakker, MD, PhD, Rolf M.F. Berger, MD, PhD, Joost P. van Melle, MD, PhD   +10 more
doaj   +1 more source