Results 31 to 40 of about 12,086,031 (341)

Cardiovascular and Renal Outcomes With Canagliflozin According to Baseline Kidney Function

Circulation, 2018
Background: Canagliflozin is approved for glucose lowering in type 2 diabetes and confers cardiovascular and renal benefits. We sought to assess whether it had benefits in people with chronic kidney disease, including those with an estimated glomerular ...
B. Neuen, T. Ohkuma, B. Neal, D. Matthews, D. de Zeeuw, K. Mahaffey, G. Fulcher, Mehul Desai, Qiang Li, H. Deng, N. Rosenthal, M. Jardine, G. Bakris, V. Perkovic   +13 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

The error of estimated GFR in predialysis care

Scientific Reports
The error of estimated glomerular filtration rate (eGFR) and its consequences in predialysis are unknown. In this prospective multicentre study, 315 predialysis patients underwent measured GFR (mGFR) by the clearance of iohexol and eGFR by 52 formulas ...
Beatriz Escamilla-Cabrera, Sergio Luis-Lima, Eduardo Gallego-Valcarce, Nuria Victoria Sánchez-Dorta, Natalia Negrín-Mena, Laura Díaz-Martín, Coriolano Cruz-Perera, Ana Monserrat Hernández-Valles, Federico González-Rinne, María José Rodríguez-Gamboa, Sara Estupiñán-Torres, Rosa Miquel-Rodríguez, María Ángeles Cobo-Caso, Patricia Delgado-Mallén, Gema Fernández-Suárez, Ana González-Rinne, Grimanesa Hernández-Barroso, Alejandra González-Delgado, Armando Torres-Ramírez, Alejandro Jiménez-Sosa, Alberto Ortiz, Flavio Gaspari, Domingo Hernández-Marrero, Esteban Luis Porrini   +23 more
doaj   +1 more source

The Urinary Glucose Excretion by Sodium–Glucose Cotransporter 2 Inhibitor in Patients With Different Levels of Renal Function: A Systematic Review and Meta-Analysis

Frontiers in Endocrinology, 2022
ObjectivePrevious evidence suggested that sodium–glucose cotransporter 2 inhibitor (SGLT2i)-mediated urinary glucose excretion (UGE) appeared to be reduced with a decrease in glomerular filtration rate.
Suiyuan Hu, Chu Lin, Xiaoling Cai, Xingyun Zhu, Fang Lv, Lin Nie, Linong Ji   +6 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Relationship of Renal Echogenicity with Renal Pathology and Function [PDF]

Childhood Kidney Diseases, 2017
Purpose Renal ultrasonography has been widely used in children with renal disease. However, the relationship of renal echogenicity with renal pathology and function in children is not well known.
Jin Hee Lee, Myung Hyun Cho, Sung Ill Chung, So Dug Lim, Kyo Sun Kim   +4 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

ULTRASONOGRAPHIC MEASUREMENT OF RENAL CORTICAL THICKNESS AND RENAL LENGTH INADULTS WITH NORMAL RENALFUNCTION [PDF]

Perspectives In Medical Research, 2019
Background/Objective: Renal cortical thickness and renal length are important indices for many renal diseases. Ultrasonography has been introduced as an effective method to determine different renal measurements.
Priyanka Racha1, Sushmitha2 ,VikasChennamaneni3
doaj  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Association between changes in renal function and clinical outcomes in anticoagulated atrial fibrillation patients with marginal renal function. A nationwide observational cohort study

Frontiers in Cardiovascular Medicine
BackgroundRenal function is one of the crucial components for determining the dose and type of oral anticoagulants in atrial fibrillation (AF) patients, and is also closely associated with the risks of stroke and bleeding.
Kyung-Yeon Lee, So-Ryoung Lee, So-Ryoung Lee, Eue-Keun Choi, Eue-Keun Choi, JungMin Choi, Hyo-Jeong Ahn, Soonil Kwon, Bongseong Kim, Kyung-Do Han, Seil Oh, Seil Oh, Gregory Y. H. Lip, Gregory Y. H. Lip, Gregory Y. H. Lip   +14 more
doaj   +1 more source