Results 131 to 140 of about 169,102 (267)

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

International Journal of Cancer, Volume 152, Issue 5, Page 879-912, 1 March 2023., 2023
Abstract Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature.
Haleigh Cavalier, Leonardo Trasande, Miquel Porta   +2 more
wiley   +1 more source

In heart failure, echocardiographic parameters of right ventricular function are powerful tools to predict renal failure

ESC Heart Failure, EarlyView.
Abstract Background Chronic kidney disease (CKD) has a high prevalence in patients with heart failure (HF) and is associated with prolonged hospitalization, increased need for intensive care and mortality. There is an urgent need to identify factors that influence the interaction between heart and kidney disorders, often described as cardiorenal ...
Alexander Reinecke, Paulina Dißmann, Norbert Frey, Oliver J. Müller, Hatim Seoudy, Johanne Frank, Derk Frank, Martina E. Spehlmann   +7 more
wiley   +1 more source

Prognostic value of advanced lung cancer inflammation index in heart failure patients: A comprehensive analysis

ESC Heart Failure, EarlyView.
Abstract Aims The prognosis of heart failure (HF) is closely linked to inflammation and nutritional status. The advanced lung cancer inflammation index (ALI) is a composite indicator consisting of several parameters used to assess inflammation and nutritional status. Our study aimed to investigate the prognostic value of ALI in HF patients. Methods The
Wentao Chen, Guihua Zhang, Qiao Lei, Huixia Lu   +3 more
wiley   +1 more source

First‐trimester screening for pre‐eclampsia and small for gestational age: A comparison of the gaussian and Fetal Medicine Foundation algorithms

International Journal of Gynecology &Obstetrics, Volume 160, Issue 1, Page 150-160, January 2023., 2023
Abstract Objective Pre‐eclampsia (PE) and small for gestational age (SGA) can be predicted from the first trimester. The most widely used algorithm worldwide is the Fetal Medicine Foundation (FMF) algorithm. The recently described Gaussian algorithm has reported excellent results although it is unlikely to be externally validated.
Berta Serrano, Erika Bonacina, Carlota Rodo, Pablo Garcia‐Manau, María Ángeles Sanchez‐Duran, María Pancorbo, Cristina Forcada, María Teresa Murcia, Ana Perestelo, Mireia Armengol‐Alsina, Manel Mendoza, Elena Carreras   +11 more
wiley   +1 more source

Inter‐atrial block as a predictor of adverse outcomes in patients with HFpEF

ESC Heart Failure, EarlyView.
Abstract Aims Inter‐atrial block (IAB), a marker of electrical atrial dysfunction, is associated with an increased risk of atrial fibrillation (AF) and adverse events in various populations. The prognostic impact of IAB in heart failure (HF) with preserved ejection fraction (HFpEF) remains unknown.
Jerremy Weerts, Sanne G.J. Mourmans, Helena Lopez‐Martinez, Mar Domingo, Arantxa Barandiarán Aizpurua, Michiel T.H.M. Henkens, Anouk Achten, Josep Lupón, Hans‐Peter Brunner‐La Rocca, Christian Knackstedt, Antoni Bayés‐Genís, Vanessa P.M. van Empel   +11 more
wiley   +1 more source

Baseline kidney function and the effects of dapagliflozin on health status in heart failure in DEFINE‐HF and PRESERVED‐HF

ESC Heart Failure, EarlyView.
Abstract Aims Sodium–glucose co‐transporter‐2 (SGLT2) inhibitors improve health status and outcomes in the setting of heart failure (HF) across the range of ejection fraction (EF). Baseline kidney disease is common in HF, complicates HF management and is strongly linked to worse health status. This study aimed to assess whether the treatment effects of
Andrew P. Ambrosy, Andrew J. Sauer, Shachi Patel, Sheryl L. Windsor, Barry A. Borlaug, Mansoor Husain, Silvio E. Inzucchi, Dalane W. Kitzman, Darren K. McGuire, Sanjiv J. Shah, Kavita Sharma, Guillermo Umpierrez, Mikhail N. Kosiborod   +12 more
wiley   +1 more source

Up‐titration of medication in patients with new‐onset heart failure with and without atrial fibrillation

ESC Heart Failure, EarlyView.
Abstract Aims Differences in guideline‐directed medical therapy (GDMT) and clinical outcomes have been observed between heart failure (HF) patients with atrial fibrillation (AF) versus those in sinus rhythm. This study evaluated the effects of up‐titration of HF therapies, consisting of beta‐blockers, angiotensin‐converting‐enzyme inhibitors (ACEis ...
Arietje J.L. Zandijk, Bernadet T. Santema, Friso D.J. Inkelaar, Martje H.L. van der Wal, Janke Warink‐Riemersma, Michiel Rienstra, Adriaan A. Voors   +6 more
wiley   +1 more source

A case of pseudoprogression in avelumab maintenance therapy for metastatic bladder cancer

IJU Case Reports, Volume 6, Issue 1, Page 5-7, January 2023., 2023
Introduction A unique phenomenon of immune therapy is pseudoprogression; however, a definite mechanism and predictive factors remain unclear. We herein report a case of pseudoprogression with avelumab maintenance therapy. Case presentation A 67‐year‐old male diagnosed with muscle‐invasive bladder cancer with lung metastasis was treated with four cycles
Nozomi Hayakawa, Eiji Kikuchi
wiley   +1 more source

Thyroid hormone replacement therapy in dialysis/renal insufficiency patients. [PDF]

Front Endocrinol (Lausanne)
Zhao X, Liu F, Yuan S, Wang F, Li C, Guo C, Zhao J.   +6 more
europepmc   +1 more source

The ADESTE trial: A phase 2 study of enibarcimab, a monoclonal antibody targeting adrenomedullin, in acute heart failure

ESC Heart Failure, EarlyView.
Abstract Aims This study aimed to conduct a phase 2 proof‐of‐concept and safety study to evaluate the effect of ENIBARCIMAB (EN), a non‐neutralizing humanized monoclonal antibody targeting the N‐terminus of adrenomedullin (ADM), administered immediately after stabilization with standard of care (SoC) treatment, in patients hospitalized for acute heart ...
Anggoro Budi Hartopo, Arinal Chairul Achyar, Hendry Purnasidha Bagaswoto, Firandi Saputra, Hasanah Mumpuni, Dyah Adhi Kusumastuti, Teguh Triyono, Usi Sukorini, Metalia Puspitasari, Budi Yuli Setianto, Mohammad Saifur Rohman, Muhammad Anshory, Yoga Waranugraha, Putri Annisa Kamila, Agustin Iskandar, Hani Susianti, Andreas Bergman, Claudia Knothe, Paola Antonini, Salvatore Di Somma   +19 more
wiley   +1 more source