Results 151 to 160 of about 2,481,937 (240)
Advanced Science, EarlyView.Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang +12 more
wiley +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
AGING MEDICINE, EarlyView.Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley +1 more source
A Bioinspired Underwater Soft Robot for Active Intravesical Liquid Delivery and Mixing
Advanced Intelligent Systems, EarlyView.A bioinspired underwater soft robot is reported that integrates an elastic strain energy‐driven soft robotic pump with a programmable flexible magnetic valve, enabling remotely controlled, programmable, and sustained liquid release and mixing. This functionality is enabled by the synergistic integration of elastic strain energy‐driven pumping and ...
Jacob Katona +7 more
wiley +1 more source
Oxalate Nephropathy in a patient with Neuroendocrine tumor receiving Long-acting Octreotide. [PDF]
CEN Case RepS V A +6 more
europepmc +1 more source
Spinal Involvement in Charge Syndrome: Implications for Management
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT CHARGE syndrome (OMIM #214800) is an autosomal dominant disorder caused by mutations in the CHD7 gene in most cases. Although originally defined by the CHARGE acronym (coloboma, heart defects, choanal atresia, growth restriction, genital hypoplasia, and ear anomalies), the recognized phenotype has expanded considerably to include highly ...
Adriana Gomes +5 more
wiley +1 more source
Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics
Angewandte Chemie, EarlyView.Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee +4 more
wiley +2 more sources
The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases. [PDF]
Arthritis Care Res (Hoboken)Kundakci B +25 more
europepmc +2 more sources
TTC21B: From Modifier to Causative Gene in Joubert Syndrome
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Biallelic pathogenic variants in TTC21B, encoding the retrograde intraflagellar transport protein IFT139, are a known cause of renal and skeletal ciliopathies. Single heterozygous variants in this gene were found to be enriched in a cohort of patients with various ciliopathy phenotypes, including three individuals with Joubert syndrome (JS), a
Valentina Serpieri +5 more
wiley +1 more source
Cross-sectional imaging in an inferior vena cava agenesis associated with antiphospholipid syndrome, lower limb, and portomesenteric deep vein thrombosis and renal insufficiency in a young patient: A rare presentation. [PDF]
Radiol Case RepLinda Sami W +2 more
europepmc +1 more source