Results 161 to 170 of about 449,086 (355)

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Management of Proteinuria in Dogs and Cats with Chronic Kidney Disease [PDF]

, 2016
Atkins, Bakris, Bianchi, Bomback, Brown, Brown, Brown, Brown, Bugbee, Christ, Finco, Grauer, Grauer, Horita, Jacob, Jenkins, Jepson, Jepson, Jonathan Elliott, King, King, Laverman, Lees, Lefebvre, LeVine, Linas, Littman, Maack, McAlister, Mizutani, Nabity, Nakamura, Pollock, Pressler, Ryan, Schjoedt, Schneider, Segev, Segev, Sent, Shelly L. Vaden, Singh, Syme, Tenhundfeld, Toblli, Vaden, Wehner   +46 more
core   +2 more sources

Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.

Journal of the American Society of Nephrology, 2017
A. Parsa, P. Kanetsky, Rui Xiao, J. Gupta, N. Mitra, Sophie Limou, D. Xie, Huichun Xu, Amanda H. Anderson, A. Ojo, J. Kusek, C. Lora, L. Hamm, Jiang He, N. Sandholm, Janina M. Jeff, Dominic E. Raj, Carsten A. Böger, E. Bottinger, S. Salimi, R. Parekh, Sharon Adler, C. Langefeld, D. Bowden, P. Groop, C. Forsblom, B. Freedman, M. Lipkowitz, Caroline S. Fox, C. Winkler, Harold I. Feldman   +30 more
semanticscholar   +1 more source

Reprogramming Tumor‐Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy

Advanced Science, EarlyView.
This study presents the sono‐sensitive nanorobot Sono@NAT10, which targets NAT10 condensates to reprogram tumor‐associated macrophages in colorectal cancer. By reducing the acetylation level of SRSF2 protein and activating HDAC10, Sono@NAT10 promotes M1 polarization, suppresses tumor progression, and strengthens immunotherapy. The approach demonstrates
Jiahao Zhu, Benjie Xu, Rui Hu, Bo Yang, Peipei Shen, Yu Xu, Xiaojun Zhang, Danqi Qian, Gang Wu, Shengjun Ji, Yutian Zhao, Ke Gu   +11 more
wiley   +1 more source

Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study

American Journal of Nephrology, 2016
E. Rhee, C. Clish, J. Wenger, Jason A. Roy, S. Elmariah, K. Pierce, Kevin Bullock, A. Anderson, R. Gerszten, H. Feldman   +9 more
semanticscholar   +1 more source

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

Advanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong, Shuguang Yang, Xiao Li, Zhuang Jin, Jianyu Ma, Zhouzhou Liao, Jinbo Li, Bo Li, Xintao Shuai, Shuqin Chen   +9 more
wiley   +1 more source

Healthy lifestyle and risk of kidney disease progression, atherosclerotic events, and death in CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.

American Journal of Kidney Diseases, 2015
A. Ricardo, C. Anderson, Wei Yang, Xiaoming Zhang, Michael J. Fischer, L. Dember, J. Fink, A. Frydrych, Nancy G. Jensvold, E. Lustigova, L. Nessel, Anna C. Porter, Mahboob Rahman, Julie A. Wright Nunes, M. Daviglus, J. Lash   +15 more
semanticscholar   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source

Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort

Kidney International Reports, 2016
F. Afshinnia, Thekkelnaycke M. Rajendiran, A. Karnovsky, Tanu Soni, Xue Wang, D. Xie, Wei Yang, T. Shafi, M. Weir, Jiang He, C. Brecklin, E. Rhee, J. Schelling, A. Ojo, H. Feldman, G. Michailidis, S. Pennathur, Lawrence J. Alan S. John W. James P. Raymond R. Appel Go Kusek Lash Townsend, L. Appel, A. Go, J. Kusek, J. Lash, R. Townsend   +22 more
semanticscholar   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source