Results 61 to 70 of about 172,875 (307)

Hyperkalemia: An adaptive response in chronic renal insufficiency [PDF]

Kidney International, 2002
Hyperkalemia is a common feature of chronic renal insufficiency, usually ascribed to impaired K+ homeostasis. However, various experimental observations suggest that the increase in extracellular [K+] actually functions in a homeostatic fashion, directly stimulating renal K+ excretion through an effect that is independent of, and additive to ...
Alan S. Segal, F. John Gennari
openaire   +3 more sources

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Identification of core genes and pathways between geriatric multimorbidity and renal insufficiency: potential therapeutic agents discovered using bioinformatics analysis

BMC Medical Genomics, 2022
Background Geriatric people are prone to suffer from multiple chronic diseases, which can directly or indirectly affect renal function. Through bioinformatics analysis, this study aimed to identify key genes and pathways associated with renal ...
Lingyun Zhang, Jiasheng Cai, Jing Xiao, Zhibin Ye   +3 more
doaj   +1 more source

Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis (the BiCARB trial)? Study protocol for a randomized controlled trial [PDF]

, 2015
Date of acceptance: 01/07/2015 © 2015 Witham et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
A Mahajan, Alison Avenell, AM Kamper, AT Johnston, B Iorio Di, BA Hout van, BT Workeneh, D Reaich, Deepa Sumukadas, Edmund J. Lamb, Geeta Hampson, H Roberts, I Brito-Ashurst, J Coresh, J Coresh, JA Eustace, JA Kraut, JA Kraut, JC Davis, JM Guralnik, JM Guralnik, K Baboolal, K Bibbins-Domingo, L Ceglia, LD Hughes, M Dobre, M Dobre, M Gaggl, Margaret M. Band, Marion E. T. McMurdo, ME McMurdo, ME McMurdo, Miles D. Witham, MR Wiederkehr, P Laukkanen, P Susantitaphong, Paul McNamee, PE Stevens, RB Haynes, RD Hays, Roberta C. Littleford, Roy L. Soiza, Simon A. Ogston, SJ Walters, T Rantanen, V Menon, WN Wennie Huang   +46 more
core   +3 more sources

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Infrainguinal reconstruction for patients with chronic renal insufficiency [PDF]

Journal of Vascular Surgery, 1993
The efficacy of autogenous infrainguinal reconstruction for patients with varying degrees of chronic renal insufficiency was reviewed because it has not been well defined.Pertinent data were retrieved from hospital records and the vascular registry for all patients with chronic renal insufficiency (serum creatine > 2 mg/dl) who required surgical ...
Magruder C. Donaldson, Anthony D. Whittemore, John A. Mannick   +2 more
openaire   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Hearing loss in geriatric hemodialysis patients

Medical Journal of Dr. D.Y. Patil University, 2015
Introduction: The aim of the study was to evaluate the hearing loss in geriatric hemodialysis patients. Materials and Methods: The study was performed on 16 geriatric hemodialysis patients (age minimum: 65, maximum: 86 years) and 16 volunteers (age ...
Caner Sahin, Ceyhun Varim
doaj   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Pure red cell aplasia and anti-erythropoietin antibodies in patients on hemodialysis: a report of two cases and a literature review

Brazilian Journal of Nephrology, 2018
Introduction: Anemia is a frequent multifactorial complication of CKD seen in patients on dialysis derived mainly from impaired erythropoietin (EPO) production.
Gabriela Lacreta, Sérgio Gardano Elias Bucharles, Gabriela Sevignani, Miguel Carlos Riella, Marcelo Mazza do Nascimento   +4 more
doaj   +1 more source