Results 51 to 60 of about 288,448 (309)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Reversible Renal Insufficiency Secondary to Extrinsic Splenic Compression of the Kidney in a Patient with Chronic Lymphocytic Leukemia

The Scientific World Journal, 2010
While increased renal venous and direct renal parenchymal pressure may cause renal insufficiency, there are no prior reports of hypersplenism secondary to chronic lymphocytic leukemia (CLL) doing so.
Miriam Hadj-Moussa, James A. Brown
doaj   +1 more source

Association of high blood pressure with renal insufficiency: role of albuminuria, from NHANES, 1999-2006.

PLoS ONE, 2012
BackgroundThe relationship between hypertension and kidney disease is complicated. Clinical trials found intense blood pressure control was not associated with alterations in glomerular filtration rate (GFR) in all patients but did slow the rate of GFR ...
Ping Yan, Xiangzhu Zhu, Haiming Li, Martha J Shrubsole, Haiming Shi, Ming-zhi Zhang, Raymond C Harris, Chuan-Ming Hao, Qi Dai   +8 more
doaj   +1 more source

Indicators of acute and persistent renal damage in adult thrombotic microangiopathy. [PDF]

PLoS ONE, 2012
BACKGROUND: Thrombotic microangiopathies (TMA) in adults such as thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are life-threatening disorders if untreated.
Firuseh Dierkes, Nikolaos Andriopoulos, Christoph Sucker, Kathrin Kuhr, Markus Hollenbeck, Gerd R Hetzel, Volker Burst, Sven Teschner, Lars C Rump, Thomas Benzing, Bernd Grabensee, Christine E Kurschat   +11 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Third-line multiple myeloma treatment of inpatients in a German cancer center: analysis of potential cost savings due to decreased renal insufficiency

Cost Effectiveness and Resource Allocation
Background Renal insufficiency is one of the most common complications in the treatment of multiple myeloma (MM). The administration of isatuximab showed improved patient outcome regarding the occurrence of renal insufficiency. Building on the results of
F. Jakobs, P. Ahmadi, V. Osterkamp, J. Jeck, U. Holtick, C. Scheid, Florian Kron   +6 more
doaj   +1 more source

Outcomes Following Coronary Artery Bypass Graft Surgery in Patients with Mild Preoperative Renal Insufficiency

Brazilian Journal of Cardiovascular Surgery
Introduction: Preoperative renal insufficiency is an independent predictor of mortality after coronary artery bypass graft (CABG) surgery. However, there are few reports aimed to evaluate the impact of mild preoperative renal insufficiency on long-term ...
Weitie Wang, Yuefeng Wang, Rihao Xu, Junwu Chai, Wei Zhou, Honglei Chen, Kai Wang, Xiangrong Kong   +7 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Comparative Study between Outcome of Percutaneous Nephrolithotomy and Extracorporeal Shock Wave Lithotripsy in Patients with Renal Insufficiency

SVU - International Journal of Medical Sciences, 2021
Background: The incidence of stone formation in patients with renal insufficiency 17.5%, complete clearance of stone in these patients need least invasive procedure with safety of kid-ney parenchyma and kidney function. Objectives:To analyze outcomes of
Mostafa AbdelRazek, Ahmad Abolyosr, Mohammed S. Abdel Kader, Ahmed M. Hassan, Omar Mohammed, Atef Fathy, Ahmed Abdelfattah*, Gamal Alsagheer   +7 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source