Results 81 to 90 of about 1,116,431 (255)

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Peripheral Neuropathy and VIth Nerve Palsy Related to Randall Disease Successfully Treated by High-Dose Melphalan, Autologous Blood Stem Cell Transplantation, and VIth Nerve Decompression Surgery

Case Reports in Medicine, 2010
Randall disease is an unusual cause of extraocular motor nerve (VI) palsy. A 35-year-old woman was hospitalized for sicca syndrome. The physical examination showed general weakness, weight loss, diplopia related to a left VIth nerve palsy, hypertrophy of
C. Foguem, P. Manckoundia, P. Pfitzenmeyer, J.-L. Dupond   +3 more
doaj   +1 more source

Effect of inhibition of nitric oxide synthase on blood pressure and renal sodium handling in renal denervated rats

Brazilian Journal of Medical and Biological Research, 2000
The role of sympathetic nerve activity in the changes in arterial blood pressure and renal function caused by the chronic administration of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was examined in sham and ...
F. Xavier, A.M.F. Magalhães, J.A.R. Gontijo   +2 more
doaj   +1 more source

Cardiopulmonary sympathetic afferent influences on renal nerve activity

, 1977
Cardiopulmonary sympathetic afferent nerves may affect renal control of intravascular volume by influencing renal sympathetic nerve activity. This influence was evaluated in alpha-chloralose anesthetized, vagotomized, sino-aortic denervated cats.
L. C. Weaver
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

18F-DOPA uptake illustration acts as an indicator for renal sympathetic activity

Frontiers in Physiology
Renal denervation (RDN) has emerged as a promising therapeutic approach for hypertension, particularly in patients with refractory hypertension. However, non-invasive measurement of the degree of renal nerve ablation has still been a challenge.
Rui Wu, Saijian Shi, Yuanjie Huang, Feng Tian, Jiqin Hou, Xiangqing Kong, Longxiang Sheng, Tao Zhang, Lijun Tang, Wei Sun   +9 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Short-term Safety and Efficiency of Cryoablation for Renal Sympathetic Denervation in a Swine Model

Chinese Medical Journal, 2015
Background: Renal sympathetic nerves are involved in the reflective activation of the sympathetic nervous system in circulatory control. Catheter-based renal denervation (RDN) ameliorated treatment-resistant hypertension safely, but 10%-20% of treated ...
Meng Ji, Li Shen, Yi-Zhe Wu, Zhi-Feng Yao, Jia-Sheng Yin, Jia-Hui Chen, Jian-Guo Jia, Ling-Juan Qiao, Peng Liu, Jun-Bo Ge   +9 more
doaj   +1 more source

Histological examination of renal nerve distribution, density, and function in humans. [PDF]

EuroIntervention, 2023
Struthoff H, Lauder L, Hohl M, Hermens A, Tzafriri AR, Edelman ER, Kunz M, Böhm M, Tschernig T, Mahfoud F.   +9 more
europepmc   +1 more source