Results 201 to 210 of about 1,621,854 (283)

Aorticorenal Ganglion Ablation Enhances Blood Pressure Reduction After Renal Denervation. [PDF]

Hypertension
Long Y, Lai Y, Ren Y, Ma X, Li D, Chen L, Liao X, Xia T, Liu Z, Ling Z, Chen Y, Zhou H, Yin Y.   +12 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Combined percutaneous auricular vagus nerve stimulation and ultrasound-guided phrenic nerve block for persistent hiccups: A case report. [PDF]

Medicine (Baltimore)
Luo Q, Wu G, Shi C, Guo Z, Wang J, Wang R, Xu X.   +6 more
europepmc   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Electroacupuncture-inspired neuroimmune modulation in sepsis: evidence appraisal and ICU trial-design priorities. [PDF]

Front Med (Lausanne)
Qian Y, Lin C, Lin H, Leng Y, Xie K, Shan Y, Xu L.   +6 more
europepmc   +1 more source

One‐Year Transcutaneous Tibial Nerve Stimulation Treatment Persistence in Lower Urinary Tract Dysfunction: Clinical and Urodynamic Associated Factors in a Prospective Observational Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims To assess 1‐year Transcutaneous Tibial Nerve Stimulation (TTNS) treatment persistence in routine clinical care and to explore clinical and urodynamic factors associated with treatment persistence in patients with lower urinary tract dysfunction (LUTD).
Damien Prat, Evelyne Castel‐Lacanal, Thibaut Brierre, Gaetane Foures, Camille Cormier, Xavier De Boissezon, David Gasq, Philippe Marque, Xavier Gamé, Emmeline Montané   +9 more
wiley   +1 more source

Renal cell carcinoma intraspinal metastases: a peripheral nerve sheath tumor mimic. Illustrative case. [PDF]

J Neurosurg Case Lessons
O'Leary S, Adams A, Ogasawara C, Prablek M, Lall R.   +4 more
europepmc   +1 more source

Fear‐Avoidance and Overactive Bladder: Toward a Mechanism‐Informed Model of Care

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Overactive bladder (OAB) is associated with substantial psychological burden, yet existing biopsychosocial frameworks acknowledge that psychological factors shape outcomes without explaining the cognitive and behavioral mechanisms through which that influence operates.
Rupal M. Patel, Andrea Wood
wiley   +1 more source