Results 1 to 10 of about 320 (119)

Central Gαi2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity

Frontiers in Endocrinology, 2022
Hypertension, a major public health issue, is estimated to contribute to 10% of all deaths worldwide. Further, the salt sensitivity of blood pressure is a critical risk factor for the development of hypertension. The hypothalamic paraventricular nucleus (
Razie Amraei, Jesse D. Moreira, Jesse D. Moreira, Richard D. Wainford, Richard D. Wainford   +4 more
doaj   +1 more source

Ablation of TRPV1-positive nerves exacerbates salt-induced hypertension and tissue injury in rats after renal ischemia-reperfusion via infiltration of macrophages

Clinical and Experimental Hypertension, 2021
Background: High-salt intake after renal ischemia/reperfusion (I/R) injury leads to hypertension and further renal injury, but the mechanisms are largely unknown.
Shuang-Quan Yu, Shuangtao Ma, Donna H. Wang   +2 more
doaj   +1 more source

The Effects of Renal Denervation on Renal Hemodynamics and Renal Vasculature in a Porcine Model. [PDF]

PLoS ONE, 2015
Recently, the efficacy of renal denervation (RDN) has been debated. It is discussed whether RDN is able to adequately target the renal nerves.We aimed to investigate how effective RDN was by means of functional hemodynamic measurements and nerve damage ...
Willemien L Verloop, Lisette E G Hubens, Wilko Spiering, Pieter A Doevendans, Roel Goldschmeding, Ronald L A W Bleys, Michiel Voskuil   +6 more
doaj   +1 more source

Renal Nerve Deafferentation Attenuates the Fall in GFR during Intravenous Infusion of Furosemide in Anesthetized Rats

Kidney & Blood Pressure Research, 2020
Introduction: Furosemide reduces the glomerular filtration rate (GFR) and increases the renal vascular resistance (RVR) despite inhibiting tubuloglomerular feedback but increases proximal tubule pressure, renin release, and renal nerve activity ...
Magali Araujo, Glenn Solis, William J. Welch, Christopher S. Wilcox   +3 more
doaj   +1 more source

The Renal Nerves in Chronic Heart Failure: Afferent and Efferent Mechanisms

Frontiers in Physiology, 2015
The function of the renal nerves has been an area of scientific and medical interest for many years. The recent advent of a minimally invasive catheter-based method of renal denervation has renewed excitement in understanding the afferent and efferent ...
Alicia Marie Schiller, Peter Ricci Pellegrino, Irving H Zucker   +2 more
doaj   +1 more source

Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension

Frontiers in Medicine, 2018
The kidneys are densely innervated with renal efferent and afferent nerves to communicate with the central nervous system. Innervation of major structural components of the kidneys, such as blood vessels, tubules, the pelvis, and glomeruli, forms a ...
Yusuke Sata, Yusuke Sata, Geoffrey A. Head, Kate Denton, Clive N. May, Markus P. Schlaich, Markus P. Schlaich, Markus P. Schlaich   +7 more
doaj   +1 more source

Electrical stimulation of renal nerves for modulating urine glucose excretion in rats

Bioelectronic Medicine, 2018
Background The role of the kidney in glucose homeostasis has gained global interest. Kidneys are innervated by renal nerves, and renal denervation animal models have shown improved glucose regulation.
Ahmad A. Jiman, Kavaljit H. Chhabra, Alfor G. Lewis, Paul S. Cederna, Randy J. Seeley, Malcolm J. Low, Tim M. Bruns   +6 more
doaj   +1 more source

Sensory Afferent Renal Nerve Activated Gαi2 Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges

Frontiers in Physiology, 2021
We have previously reported that brain Gαi2 subunit proteins are required to maintain sodium homeostasis and are endogenously upregulated in the hypothalamic paraventricular nucleus (PVN) in response to increased dietary salt intake to maintain a salt ...
Jesse D. Moreira, Jesse D. Moreira, Kayla M. Nist, Kayla M. Nist, Casey Y. Carmichael, Casey Y. Carmichael, Jill T. Kuwabara, Jill T. Kuwabara, Richard D. Wainford, Richard D. Wainford   +9 more
doaj   +1 more source

Renal Perfusion and Renal Nerve Activity [PDF]

Journal of the American Society of Nephrology, 2019
In the study by Haddock et al. ,[1][1] it was both interesting and exciting to see that such differences in regional kidney blood flow could be shown in humans over short time intervals. They suggest in their discussion that this tool could be useful in studies of renal denervation, because ...
openaire   +2 more sources

Blood Pressure Response to Main Renal Artery and Combined Main Renal Artery Plus Branch Renal Denervation in Patients With Resistant Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSingle‐electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)‐lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure.
Karl Fengler, Sebastian Ewen, Robert Höllriegel, Karl‐Philipp Rommel, Saaraaken Kulenthiran, Lucas Lauder, Bodo Cremers, Gerhard Schuler, Axel Linke, Michael Böhm, Felix Mahfoud, Philipp Lurz   +11 more
doaj   +1 more source