Results 141 to 150 of about 532,354 (260)

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

WCN25-2529 RENAL BIOPSIES IN PREGNANCY AND POST-PARTUM: HISTOPATHOLOGICAL EVALUATION

Kidney International Reports
Malathi CV, Jansi Prema KS, Anila Abraham Kurien   +2 more
doaj   +1 more source

Albuminuria and Renal Pathology in Right Heart Failure: Congestive Kidney? [PDF]

Kidney Int Rep, 2022
Terashita M, Taki Y, Sumi H, Sugaya T, Koike J, Kamijo-Ikemori A, Shibagaki Y, Tominaga N.   +7 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Renal pathology in adult and paediatric population of Japan: review of the Japan renal biopsy registry database from 2007 to 2017. [PDF]

J Nephrol, 2023
Goto K, Imaizumi T, Hamada R, Ishikura K, Kosugi T, Narita I, Sugiyama H, Shimizu A, Yokoyama H, Sato H, Mauryama S.   +10 more
europepmc   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Continuing medical education in renal pathology: current practices and needs among nephrologists. [PDF]

BMC Med Educ
Han Q, Yuan J, Zhao L, Liu F.
europepmc   +1 more source

An Accelerated Pipeline for Multi-label Renal Pathology Image Segmentation at the Whole Slide Image Level. [PDF]

Proc SPIE Int Soc Opt Eng, 2023
Leng H, Deng R, Asad Z, Womick RM, Yang H, Wan L, Huo Y.   +6 more
europepmc   +1 more source

World small animal veterinary association renal pathology initiative: classification of glomerular diseases in dogs [PDF]

, 2015
Aresu, L, Brovida, C, Brown, C A, Cianciolo, R E, Cowgill, L D, Heiene, R, James, C, Jansen, J H, Kass, PH, Lees, G E, Mohr, F C, Polzin, D J, Spangler, W L, Syme, H M, Vaden, S L, van de Lugt, JJ, van Dongen, A M   +16 more
core   +2 more sources