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Claudins in Renal Physiology and Pathology. [PDF]

open access: yesGenes (Basel), 2020
Claudins are integral proteins expressed at the tight junctions of epithelial and endothelial cells. In the mammalian kidney, every tubular segment express a specific set of claudins that give to that segment unique properties regarding permeability and selectivity of the paracellular pathway.
Prot-Bertoye C, Houillier P.
europepmc   +6 more sources

Renal physiology of pregnancy. [PDF]

open access: yesAdv Chronic Kidney Dis, 2013
Pregnancy involves remarkable orchestration of physiologic changes. The kidneys are central players in the evolving hormonal milieu of pregnancy, responding and contributing to the changes in the environment for the pregnant woman and fetus. The functional impact of pregnancy on kidney physiology is widespread, involving practically all aspects of ...
Cheung KL, Lafayette RA.
europepmc   +6 more sources

The roles of hydrogen sulfide in renal physiology and disease states. [PDF]

open access: yesRen Fail, 2022
Hydrogen sulfide (H2S), an endogenous gaseous signaling transmitter, has gained recognition for its physiological effects. In this review, we aim to summarize and discuss existing studies about the roles of H2S in renal functions and renal disease as ...
Feng J, Lu X, Li H, Wang S.
europepmc   +2 more sources

Effects of high altitude on renal physiology and kidney diseases. [PDF]

open access: yesFront Physiol, 2022
The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible ...
Wang SY, Gao J, Zhao JH.
europepmc   +2 more sources

Renal physiology of glucose handling and therapeutic implications. [PDF]

open access: yesNephrol Dial Transplant, 2020
The rationale for using sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes (T2D) has evolved over the last decade. Due to the effects on glucosuria and body weight loss, SGLT2 inhibitors were originally approved for ...
Cherney DZ, Kanbay M, Lovshin JA.
europepmc   +2 more sources

Effect of flipped classroom methodology on the student performance of gastrointestinal and renal physiology entrants and repeaters. [PDF]

open access: yesBMC Med Educ, 2020
Background Physiology is a subject that is considered difficult; it is associated with academic failure and causes high levels of stress and anxiety in students.
Sánchez JC   +5 more
europepmc   +2 more sources

The Renal Physiology of Pendrin-Positive Intercalated Cells.

open access: yesPhysiol Rev, 2020
Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl- absorption and HCO3- secretion, largely through
Wall SM, Verlander JW, Romero CA.
europepmc   +2 more sources

Physiology and Pathophysiology of Renal Aquaporinsa [PDF]

open access: bronzeJournal of the American Society of Nephrology, 1999
Abstract. The discovery of aquaporin membrane water channels by Agre and coworkers answered a long-standing biophysical question of how water specifically crosses biologic membranes, and provided insight, at the molecular level, into the fundamental physiology of water balance and the pathophysiology of water balance disorders.
Søren Nielsen   +5 more
openalex   +6 more sources

Hydrogen Sulfide in Renal Physiology and Disease. [PDF]

open access: yesAntioxid Redox Signal, 2016
SIGNIFICANCE Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission ...
Feliers D, Lee HJ, Kasinath BS.
europepmc   +2 more sources

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. [PDF]

open access: yesDiabetologia, 2018
The concentration of glucose in plasma is held within narrow limits (4-10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is not lost in the urine.
Ghezzi, Chiara   +2 more
core   +2 more sources

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