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Claudins in Renal Physiology and Pathology. [PDF]
Claudins are integral proteins expressed at the tight junctions of epithelial and endothelial cells. In the mammalian kidney, every tubular segment express a specific set of claudins that give to that segment unique properties regarding permeability and selectivity of the paracellular pathway.
Prot-Bertoye C, Houillier P.
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Renal physiology of pregnancy. [PDF]
Pregnancy involves remarkable orchestration of physiologic changes. The kidneys are central players in the evolving hormonal milieu of pregnancy, responding and contributing to the changes in the environment for the pregnant woman and fetus. The functional impact of pregnancy on kidney physiology is widespread, involving practically all aspects of ...
Cheung KL, Lafayette RA.
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The roles of hydrogen sulfide in renal physiology and disease states. [PDF]
Hydrogen sulfide (H2S), an endogenous gaseous signaling transmitter, has gained recognition for its physiological effects. In this review, we aim to summarize and discuss existing studies about the roles of H2S in renal functions and renal disease as ...
Feng J, Lu X, Li H, Wang S.
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Effects of high altitude on renal physiology and kidney diseases. [PDF]
The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible ...
Wang SY, Gao J, Zhao JH.
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Renal physiology of glucose handling and therapeutic implications. [PDF]
The rationale for using sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes (T2D) has evolved over the last decade. Due to the effects on glucosuria and body weight loss, SGLT2 inhibitors were originally approved for ...
Cherney DZ, Kanbay M, Lovshin JA.
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Effect of flipped classroom methodology on the student performance of gastrointestinal and renal physiology entrants and repeaters. [PDF]
Background Physiology is a subject that is considered difficult; it is associated with academic failure and causes high levels of stress and anxiety in students.
Sánchez JC+5 more
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The Renal Physiology of Pendrin-Positive Intercalated Cells.
Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl- absorption and HCO3- secretion, largely through
Wall SM, Verlander JW, Romero CA.
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Physiology and Pathophysiology of Renal Aquaporinsa [PDF]
Abstract. The discovery of aquaporin membrane water channels by Agre and coworkers answered a long-standing biophysical question of how water specifically crosses biologic membranes, and provided insight, at the molecular level, into the fundamental physiology of water balance and the pathophysiology of water balance disorders.
Søren Nielsen+5 more
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Hydrogen Sulfide in Renal Physiology and Disease. [PDF]
SIGNIFICANCE Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission ...
Feliers D, Lee HJ, Kasinath BS.
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Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. [PDF]
The concentration of glucose in plasma is held within narrow limits (4-10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is not lost in the urine.
Ghezzi, Chiara+2 more
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