Results 111 to 120 of about 3,116,502 (374)

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
core   +1 more source

The Emerging 4D Printing of Shape‐Memory Thermomorphs for Self‐Adaptative Biomedical Implants

Advanced Functional Materials, EarlyView.
4D printing enables the creation of smart implants that adapt to changing conditions in the human body over time. At the core of this technology are shape‐memory thermomorphs (SMTMs). This review offers an in‐depth analysis of 4D printing with SMTMs, emphasizing the latest advancements in smart materials, stimuli, programming principles, and their ...
Aixiang Ding, Fang Tang, Eben Alsberg
wiley   +1 more source

Renal Resistive Index Is Associated With Inactive Matrix Gla (γ‐Carboxyglutamate) Protein in an Adult Population‐Based Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Increased renal resistive index (RRI) has been associated with target organ damage as well as renal and cardiovascular outcomes. Matrix Gla (γ‐carboxyglutamate) protein (MGP) is a strong inhibitor of soft tissue calcification.
David A. Jaques, Edward Pivin, Menno Pruijm, Daniel Ackermann, Idris Guessous, Georg Ehret, Fang‐Fei Wei, Jan A. Staessen, Antoinette Pechère‐Bertschi, Cees Vermeer, Bruno Vogt, Michel Burnier, Pierre‐Yves Martin, Murielle Bochud, Belen Ponte   +14 more
doaj   +1 more source

Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury [PDF]

, 2020
Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and ...
Basta, Jeannine, Griggs, David W, Prinsen, Michael J, Rauchman, Michael, Robbins, Lynn, Stout, Lisa   +5 more
core   +1 more source

Role of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiology.

AJP - Renal Physiology, 2013
Exchange proteins directly activated by cAMP [Epac(s)] were discovered more than a decade ago as new sensors for the second messenger cAMP. The Epac family members, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small
Shi-kun Yang, Li Xiao, Jun Li, Fuyou Liu, Lin Sun, Y. Kanwar   +5 more
semanticscholar   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Cardiac lipotoxicity and fibrosis underlie impaired contractility in a mouse model of metabolic dysfunction‐associated steatotic liver disease

FASEB BioAdvances
The leading cause of death among patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) is cardiovascular disease. A significant percentage of MASLD patients develop heart failure driven by functional and structural alterations in
Olufunto O. Badmus, Alexandre A. daSilva, Xuan Li, Lucy C. Taylor, Jennifer R. Greer, Andrew R. Wasson, Karis E. McGowan, Parth R. Patel, David E. Stec   +8 more
doaj   +1 more source

Prognostic robustness of serum creatinine based AKI definitions in patients with sepsis: a prospective cohort study [PDF]

, 2015
Background: It is unclear how modifications in the way to calculate serum creatinine (sCr) increase and in the cut-off value applied, influences the prognostic value of Acute Kidney Injury (AKI).
Dhondt, Annemieke, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond, Vanmassenhove, Jill   +4 more
core   +2 more sources