Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao+12 more
wiley +1 more source
Processing and clearance of atrial natriuretic factor [PDF]
Gerbes, Alexander L.+2 more
core +1 more source
American Journal of Physiology-Renal Physiology Collections: Hypertension.
Klemens CA, Staruschenko A.
europepmc +1 more source
The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology [PDF]
Fenghua Zeng+2 more
openalex +1 more source
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang+13 more
wiley +1 more source
The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases [PDF]
Abdala, Ana P+13 more
core +1 more source
Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease. [PDF]
Musolino M+5 more
europepmc +1 more source
IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu+10 more
wiley +1 more source
The Renal Physiology of Pendrin-Positive Intercalated Cells.
Wall SM, Verlander JW, Romero CA.
europepmc +1 more source