Results 281 to 290 of about 316,846 (352)

Tolvaptan as a tool in renal physiology.

Am J Physiol Renal Physiol, 2014
Miranda CA, Lee JW, Chou CL, Knepper MA.
europepmc   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science, EarlyView.
Prevention and treatment of diabetic kidney disease (DKD) have become a major global public health challenge. This study shed new light on the underlying pathogenic mechanisms of podocyte injury in DKD and highlights the therapeutic potential of mitigating podocyte injury through inhibition of the RIPK3/NF‐κB p65‐mediated inflammatory response as a ...
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
wiley   +1 more source

LncDARS‐AS1 Regulates ATP1A1 Stability and Enhances Na+/K+ ATPase Activity to Promote Osteosarcoma Metastasis

Advanced Science, EarlyView.
This study identifies LncDARS‐AS1 as a novel oncogenic regulator that stabilizes ATP1A1 and enhances Na⁺/K⁺ ATPase activity, promoting osteosarcoma metastasis. Targeting the LncDARS‐AS1/ATP1A1/NKA axis, including pharmacological inhibition with digoxin, offers promising opportunities for the development of new therapeutic strategies against ...
Mingxian Xu, Jiatian Wei, Xiaoyu Feng, Qinkai Zhang, Jian Chen, Xinyue Wang, Xiudan Zhan, Bing Lu, Weitang Guo, Mingzhe Cheng, Renxuan Huang, Shao Xu, Changye Zou   +12 more
wiley   +1 more source

Cardiorenal Syndrome in Adults with Congenital Heart Disease. [PDF]

J Clin Med
Upadhyay S, Dodeja AK, Toro-Salazar O, Fairchild W, Han F.   +4 more
europepmc   +1 more source

Nanoscale Metal‐Organic Framework‐Based Self‐Monitoring Oxygen Economizer and ROS Amplifier for Enhanced Radiotherapy‐Radiodynamic Therapy

Advanced Science, EarlyView.
A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du, Qiang Wen, Ting Han, Jiongyu Ren, Mingyu Wang, Yunpeng Dai, Xiaoguang Ge, Lu Li, Junzhi Liu, Shi Gao   +9 more
wiley   +1 more source

Exploring student preferences with a Q-sort: the development of an individualized renal physiology curriculum.

Adv Physiol Educ, 2015
Roberts JK, Hargett CW, Nagler A, Jakoi E, Lehrich RW.   +4 more
europepmc   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

AI based automatic measurement of split renal function in [¹⁸F]PSMA-1007 PET/CT. [PDF]

EJNMMI Rep
Valind K, Ulén J, Gålne A, Jögi J, Minarik D, Trägårdh E.   +5 more
europepmc   +1 more source

Effect of Renal Denervation on Early and Late Stages of Diabetic Nephropathy. [PDF]

FASEB J
Xu B, Lowe M, Levchenko V, Morales MN, Klemens CA, Banek CT, Staruschenko A.   +6 more
europepmc   +1 more source

The External Validation of SACrA (Sex, Albumin, Creatinine, and APACHE II) Score for Predicting Nonemergent Renal Replacement Therapy Initiation: A Retrospective Study Based on the Medical Information Mart for Intensive Care - Version IV Database. [PDF]

Cureus
Yamamoto S, Suzuki G, Nishioka S, Kobori T, Masuyama Y, Serizawa H, Nakamichi Y, Honda M.   +7 more
europepmc   +1 more source