Results 291 to 300 of about 3,239,906 (356)

Editorial: Balancing act: exploring the impact of steroid hormones, diets/supplements, and new drugs on renal function. [PDF]

Front Physiol
Gomes GN, Fernandez R, Leite-Dellova DCA, Casarini DE, Yanes Cardozo LL.   +4 more
europepmc   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Anti-Inflammatory and Anti-apoptotic Effects of Phosphodiesterase Inhibitors Against Streptozocin-induced Diabetic Nephropathy. [PDF]

In Vivo
Mehanna OM, Elesawy BH, Elaskary A, Hassan MGM, Ahmed WMS, El Monsef ASA, Abbas MAM, Hammad AM, Elgazzar UB, Gabr NM, El-Sharnouby M, Sharahili AI, Khalifa MM.   +12 more
europepmc   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks

Advanced Science, EarlyView.
This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen, Qing Zhao, Wentao Fu, Weixian Chen, Xiaoqian Zhang, Gaiying Ye, Qinglei Meng, Liyuan Shao, Qian Ma, Lin Zhao, Ying Zhao, Weihua Guo   +11 more
wiley   +1 more source

Same disease, different outcomes: a retrospective cohort study of COVID-19-associated AKI across Brazil's dual-tiered healthcare system. [PDF]

J Bras Nefrol
Faria NP, Suassuna JHR, Sousa CAM, Freire SM, Gomes CLR.   +4 more
europepmc   +1 more source

Prediction value of respiratory permutation entropy for hemodynamic instability events in critically ill patients with sepsis. [PDF]

BMC Infect Dis
Zhang J, Xu X, Jin X, Li R, Li J, Hou Y, Wang X, Wang G.   +7 more
europepmc   +1 more source

Comparative Study on the Efficacy of Different Antihypertensive Classes in Early-Stage Hypertension with Renal Function Consideration.

J Pharm Bioallied Sci
Chaudhary MD, Shah S, Shah H, Gupta S, Saiyed F, Saiyad H.   +5 more
europepmc   +1 more source